1. Two new amides from the seeds of Coix lacryma-jobi var. lacryma-jobi.
- Author
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Yin, Xin, Zhu, Wei-qian, Zhou, Yong-qiang, Hu, Rui-hang, Wei, Xin, Feng, Ting-ting, and Zhou, Ying
- Subjects
AMIDES ,SEEDS ,SPERMIDINE ,CELL lines ,CANCER cells ,COLE crops - Abstract
Phytochemical investigation of the seeds of Coix lacryma-jobi var. lacryma-jobi resulted in the isolation of eight compounds, including two new structures, coixdines A-B (1-2) and six known compounds (3-8). The structures of these compounds were determined by 1 D and 2 D NMR spectra referring to the literatures, together with HR-MS analysis. Coixdine A and B are first examples of spermidine skeleton in genus Coix. In the present paper, all compounds were evaluated for the cytotoxicity against two cancer cell lines (CT-26 and BxPC-3) in vitro, and none of the compounds exhibited obvious cytotoxic activity. The present investigation suggests that these amides seem to be of great chemotaxonomic value for C. lacryma-jobi. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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