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Your search keyword '"Kulsha, Andrey V."' showing total 1 results
Start Over Author "Kulsha, Andrey V." Topic cancer cells
1 results on '"Kulsha, Andrey V."'

1. Metal‐(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple‐Negative Breast Cancer.

Author

Katkova, Svetlana A., Bunev, Alexander S., Gasanov, Rovshan E., Khochenkov, Dmitry A., Kulsha, Andrey V., Ivashkevich, Oleg A., Serebryanskaya, Tatiyana V., and Kinzhalov, Mikhail A.

Subjects
TRIPLE-negative breast cancer, CANCER cells, ANTINEOPLASTIC agents, CISPLATIN, DRUG discovery, PLATINUM
Abstract

Hydrolytically stable PdII and PtII complexes supported by acyclic diaminocarbene ligands represent a novel class of structural organometallic anticancer agents exhibiting nanomolar antiproliferative activity in a panel of cancer cell lines (IC50 0.07–0.81 μM) and up to 300‐fold selectivity for cancer cells over normal primary fibroblasts. The lead drug candidate was 300 times more potent than cisplatin in vitro and showed higher efficacy in reducing the growth of aggressive MDA‐MB‐231 xenograft tumors in mice. [ABSTRACT FROM AUTHOR]

Published
2024
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