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Start Over Author "Akslen, L.A." Topic cancer in women
1 results on '"Akslen, L.A."'

1. Glomeruloid microvascular proliferation is associated with p53 expression, germline BRCA1 mutations and an adverse outcome following breast cancer.

Author

Goffin, J.R., Straume, O., Chappuis, P.O., Brunet, J.-S., Bégin, L.R., Hamel, N., Wong, N., Akslen, L.A., Foulkes, W.D., and Bégin, L R

Subjects
BREAST cancer, NEOVASCULARIZATION, SURVIVAL analysis (Biometry), CANCER in women, PROTEIN metabolism, SURVIVAL, RESEARCH, GENETIC mutation, ENDOTHELIUM, BRCA genes, RESEARCH methodology, PROGNOSIS, METASTASIS, EVALUATION research, CELL division, TUMOR classification, COMPARATIVE studies, PATHOLOGIC neovascularization, IMMUNOENZYME technique, BREAST tumors
Abstract

Glomeruloid microvascular proliferation (GMP) in breast cancer independently adversely affected survival (relative risk 1.9, 95% CI: 1.2-3.0), particularly among women who received adjuvant chemotherapy (10-year survival 27 vs 69%, P=0.0003), and was significantly associated with p53 overexpression and BRCA1 germline mutations. The presence of GMP may influence treatment decisions. [ABSTRACT FROM AUTHOR]

Published
2003
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