1. Prospective trial of radiotherapy for patients 80 years of age or older with squamous cell carcinoma of the thoracic esophagus
- Author
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Kawashima, Mitsuhiko, Kagami, Yoshikazu, Toita, Takafumi, Uno, Takashi, Sugiyama, Masato, Tamura, Yoichirio, Hirota, Saeko, Fuwa, Nobukazu, Hashimoto, Mitsumasa, Yoshida, Hiroshi, Shikama, Naoto, Kataoka, Masaaki, Akuta, Keizo, Sasaki, Kinro, Tamamoto, Tetsuro, Nemoto, Kenji, Ito, Hisao, Kato, Hoichi, Yamada, Shogo, and Ikeda, Hiroshi
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ESOPHAGEAL cancer , *SQUAMOUS cell carcinoma , *CANCER radiotherapy complications , *ELECTROTHERAPEUTICS , *CANCER treatment , *CANCER patients - Abstract
Purpose: To assess the safety and efficacy of external beam radiotherapy for elderly patients with esophageal cancer. Methods and Materials: A trial testing external beam radiotherapy (66 Gy within 6.5 weeks) as a single-modality treatment was performed for biopsy-proven squamous cell carcinoma of the thoracic esophagus clinically staged as Stage I and IIA (T1–T3N0M0, International Union Against Cancer, 1987) in patients aged ≥80 years. Results: From January 1999 through December 2002, 51 evaluable patients (35 men and 16 women) with a median age of 83 years (range, 80–91 years) were enrolled from 22 institutions. Of the 51 patients, 18 (35%) had Stage T1 and 33 (65%) had Stage T2–T3 disease. Radiotherapy could be completed in 47 patients (92%) within 43–58 days (median, 49). The actuarial incidence of Grade 3 or worse cardiopulmonary complications at 3 years was 26%, with 3 early deaths, and correlated significantly with the size of the anteroposterior radiotherapy portals. The median survival time and overall survival rate at 3 years was 30 months and 39% (95% confidence interval, 25–52%), respectively. Conclusion: The results of high-dose radiotherapy in octogenarians are comparable to those in younger patients, but meticulous treatment planning and quality control is required. [Copyright &y& Elsevier]
- Published
- 2006
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