1. m6A-immune-related lncRNA prognostic signature for predicting immune landscape and prognosis of bladder cancer.
- Author
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Feng, Zi-Hao, Liang, Yan-Ping, Cen, Jun-Jie, Yao, Hao-Hua, Lin, Hai-Shan, Li, Jia-Ying, Liang, Hui, Wang, Zhu, Deng, Qiong, Cao, Jia-Zheng, Huang, Yong, Wei, Jin-Huan, Luo, Jun-Hang, Chen, Wei, and Chen, Zhen-Hua
- Subjects
BLADDER cancer ,LINCRNA ,PEARSON correlation (Statistics) ,DISEASE risk factors ,CANCER prognosis ,SURVIVAL analysis (Biometry) - Abstract
Background: N6-methyladenosine (m6A) related long noncoding RNAs (lncRNAs) may have prognostic value in bladder cancer for their key role in tumorigenesis and innate immunity.Methods: Bladder cancer transcriptome data and the corresponding clinical data were acquired from the Cancer Genome Atlas (TCGA) database. The m6A-immune-related lncRNAs were identified using univariate Cox regression analysis and Pearson correlation analysis. A risk model was established using least absolute shrinkage and selection operator (LASSO) Cox regression analyses, and analyzed using nomogram, time-dependent receiver operating characteristics (ROC) and Kaplan-Meier survival analysis. The differences in infiltration scores, clinical features, and sensitivity to Talazoparib of various immune cells between low- and high-risk groups were investigated.Results: Totally 618 m6A-immune-related lncRNAs and 490 immune-related lncRNAs were identified from TCGA, and 47 lncRNAs of their intersection demonstrated prognostic values. A risk model with 11 lncRNAs was established by Lasso Cox regression, and can predict the prognosis of bladder cancer patients as demonstrated by time-dependent ROC and Kaplan-Meier analysis. Significant correlations were determined between risk score and tumor malignancy or immune cell infiltration. Meanwhile, significant differences were observed in tumor mutation burden and stemness-score between the low-risk group and high-risk group. Moreover, high-risk group patients were more responsive to Talazoparib.Conclusions: An m6A-immune-related lncRNA risk model was established in this study, which can be applied to predict prognosis, immune landscape and chemotherapeutic response in bladder cancer. [ABSTRACT FROM AUTHOR]- Published
- 2022
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