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Introduction: Ewing sarcomas are rare tumors (3% of malignant tumors in children). Standardized management and multidisciplinary approach is carried in our context for a long time. The purpose of this study was to describe clinical profiles and therapeutic outcomes. Patients and Methods: This is a retrospective descriptive and analytical study conducted in the Oncology and Radiation Therapy Center of University Hospital of Casablanca from 2006 to 2010. Patients with histology and immuno-histo-chemistry confirming the diagnosis of Ewing's Sarcoma (ES) and whose file were assessable were included. Data were analyzed with SPSS 20. Univariate analysis focused on the socio-demographic and clinico-radiological. Survival was calculated by the Kaplan-Meier method and the log rank test (P ≤ 0.05). Results: 32 patients were included, mean age was18 years, sex ratio (M/F) 1.5. The tumor was mainly in bone (87.5%). The average tumor size was 10.6 cm. Two cases have been reported synchronous metastasis. The treatment combined respectively chemotherapy, surgery and radiotherapy in nine patients; chemotherapy and surgery were associated in seven patients, neoadjuvant and adjuvant chemotherapy combined radiotherapy were administrated in 12 patients; 4 patients received chemotherapy alone. The average follow-up was 44 months (median = 43.5 months), the average time recurrence was 22.9 months. Overall survival was 78% and disease-free survival was 56%. The overall survival was better (79.2 %) for chilhood group (age ≤ than 20 years) than adult group >20-year-old (75%). Conclusion: The management of Ewing's sarcoma is well conducted in our center. The outcomes that we obtained are encouraging to continue. [ABSTRACT FROM AUTHOR]

The ovarian choriocarcinoma is a malignant germinal tumor, mainly affecting young women and characterized by the presence of malignant cells cytotrophoblastique and scyncitiotrophoblastique. They may be gestational (most common) or non-gestational (primitive). Destinction between the two types is difficult and requires the use of DNA analysis. We report a case of patient followed in our department for ovarian choriocarcinoma treated with surgery first followed by chemotherapy based on bleomycin, etoposide and platamine for 6 cycles. After a decline of 18 months the patient is in complete remission clinical, biological and radiological. [ABSTRACT FROM AUTHOR]

Objective of the Study: The aim of our study was to provide epidemiological and evolutionary profile of nasopharyngeal carcinoma in children under 15 years, as well as showing the experience of our service. Patients and Methods: Retrospective study on nine children with nasopharyngeal carcinoma, treated with radiotherapy-oncology at the University Hospital Ibn Rushd Casablanca, between 2004 and 2009. Results: The average age of patients was 11 years, the sex ratio was 1.6, the average consultation time was 4.3 months. Apart from a case of embryonal rhabdomyosarcoma, all tumors were undifferentiated nasopharyngeal carcinoma-type (UCNT). According to the classification of the American Joint Committee on Cancer had: T4 in 45% and T3 in 55%. N0 11%, 22% N1, 11% N2 and N3 in 56%. One child was diagnosed with pulmonary metastases at diagnosis. Treatment consisted of induction chemotherapy based on adriamycin and cisplatin combination followed by concomitant chemo radiotherapy 66-70 GY conventional fractionation. We had two deaths during treatment, and the evolution was marked by a complete remission in 55%, an increase in 11%, only one local recurrence and metastasis in 11%. The evaluation of late complications of radiotherapy revealed xerostomia in all patients with sequelae hearing loss and nasal synechia in a single patient. Conclusion: Nasopharyngeal carcinoma in children is a very special form characterized by an aggressive character. Early diagnosis and appropriate technology can improve prognosis and reduce complications. [ABSTRACT FROM AUTHOR]

Introduction: Squamous cell cancer of the anal canal is a rare tumor with loco-regional evolution often slow, its management is multidisciplinary. Methods: This is a retrospective study conducted at the Oncology Centre in Casablanca, collects 42 cases of patients treated for anal canal cancer during the period from January 2005 to December 2008. The aim of our study was to evaluate our results in terms of management of squamous cell carcinoma of the anal canal. Results: The average age of our patients was 64 years with extremes ranging from 38 to 85 years. The average period of consultation was 10 months. All cases were confirmed by biopsy: it was squamous cell carcinoma in all cases. Patients were classified, with reference to the TNM classification - T1 in 2 cases, T2 in 20 cases, T3 in 10 cases and T4 in 10 cases, lymph nodes were found in 20 patients at initial examination (N2 in 12 cases and 8 cases in N3). The treatment consisted of radiotherapy alone in three patients, chemotherapy based platamine and 5-fluorouracile (for 3 to 4 cycles), followed by a combination radio-chemotherapy with weekly platamine in 22 patients, a combination radio-chemotherapy immediately in 15 patients and radiotherapy followed by brachytherapy in two patients. After a mean of 24 months, 24 patients in complete remission, 15 recurrences, 2 lost seen and 1 death. Patients who developed recurrence were treated by surgery in eight cases and second-line chemotherapy based cisplatine/5FU or capecitabine in seven cases, with stable disease in five patients and treatment failure in 10 patients. [ABSTRACT FROM AUTHOR]

Introduction: Locally advanced breast cancer forms required neoadjuvant chemotherapy to facilitate breast conserving surgery. The purpose of our study was to determine the impact of both chemotherapy protocols on the prognosis. Patients and Methods: This is a descriptive and analytical retrospective study from 2008 to 2010 in "Centre Mohammed VI pour le traitement des cancers" of University Hospital of Casablanca., We included patients with locally advanced breast cancer who received neoadjuvant chemotherapy. Other histological types were excluded. The capture and analysis of data was done using SPSS 20 and the calculation of survival rates was done by the Kaplan-Meier method and the log-rank test. Results: Included were 102 cases of breast carcinoma. The average age was 46.5 years (24-84 years). The sex ratio women/men was 5.4. Infiltrative ductal carcinoma represented 95.3%, 36.3% of tumors were classified SBRIII and 98.1 % for stage IIIb. The chemotherapy regimens were administered AT50 (53.9%) and AC60 (46.1%). Analysis of surgical specimens has noted that 48% of tumors were classified Grade 1 Knight or MT Sataloff, 13.8% Grade 2 or TB and 7.8% Grade 3 or TC. Depending on the status of N Sataloff, 50% of patients were classified NA. Overall survival was 96.4% with an average of 32.36 months followed. Disease-free survival was 94%. A difference in survival in favor of AT50 protocol (97.8%) compared to the AC60 (94.7%) protocol was noted (P = 0.8). Conclusion: Neoadjuvant chemotherapy was not higly used in our center. The results showed a good response of breast cancers to the chemotherapy without superiority between AT50 and AC60. [ABSTRACT FROM AUTHOR]

Abstract: The breast metastases resulting of vulvar carcinoma are very rare, and represent exceptionally the first manifestation of the disease. We report the case of a 42 year-old patient who underwent a treatment because of vulvar epidermoid carcinoma, right away metastatic at the level of the inguinal ganglia. The treatment consisted in a total vulvectomy with bilateral ganglial curretage, followed by external radiotherapy about the perineum and the inguinal ganglia. Three months after the end of her treatment, the patient presented with a nodula on the left outer breast with features of malignancy noticed by clinic and mammographic examination. The histologic study of the mammary biopsy showed epidermoid carcinoma of likely metastatic origin. A left Patey has been realized and confirmed the metastatic localization of epidermoid carcinoma with axillary ganglial metastasis (2N±7). Besides, this patient presented a right cervical ganglial parcel that the biopsy showed a metastatic localization of a vulvar carcinoma. A palliative chemotherapy type cyclophosphamid, adriblastin, cisplatine (CAP) has been admistrated during three cycles spaced out three weeks. The patient died 11 months after the supervene of the cerebral metastasis. We present this case because its rarety and to show the possibility of metastasis at the level of breast due to vulvar cancer. The clinicians must remember this possible tropism of the vulvar cancer for the breast, not only during the supervision and the complete examination as regards the disease spreading but also when the affection revealed unknown primary tumor. The diagnostic orientation is based on the mammography and the mammary biopsy. In this stage, the treatment is unfortunately palliative, the survival until a year is not more than 20%. [Copyright &y& Elsevier]