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Photodynamic therapy (PDT) of cancer has been known for over twenty years and is based on the dye-sensitized photooxidation of different biological targets in the tumoral tissue, yielding to a photochemically induced cell's death via mainly apoptotic pathways. The effectiveness of this therapy depends on the photophysical and photochemical properties of the photosensitizer-drug. The purpose of this paper is to evaluate a series of aluminium phthalocyanine sensitizers compounds, in terms of photodynamic activity correlation with their structure using standard human dysplazic oral kerotinocytes cell line (DOK). The photodynamic action of some aluminium sulphonated-phthalocyanines, with different sulphonation degree (AlS2Pc, AlS4Pc), is discussed in this matter. The in vitro photodynamic treatment (PDT) induced a drastic lethal effect on DOK cells attributed to the active singlet oxygen photochemically generated by aluminium sulphonatedphthalocyanines. The tested photosensitizers induce early membrane damage and upon irradiation AlS2Pc compound is the most efficient in actively killing the tumoral cells. [ABSTRACT FROM AUTHOR]

Photodynamic therapy (PDT) is a recent acquisition in the treatment of cutaneous premalignant and malignant lesions, based upon the administration or induction of the synthesis of a photosensitizer in the tumoral tissue, followed by the illumination of the target area using a radiation with an adequate wavelength. This paper aims to review the main molecular, cellular and systemic mechanistic aspects involved in the in vivo effects of PDT, with emphasis on apoptosis and autophagy induction in tumoral cells, local vascular destruction and immune response alteration. [ABSTRACT FROM AUTHOR]

Photodynamic therapy (PDT) is a recent acquisition in the treatment of cutaneous premalignant and malignant lesions, based upon the administration or induction of the synthesis of a photosensitizer in the tumoral tissue, followed by the illumination of the target area using a radiation with an adequate wavelength. This paper aims to review the main molecular, cellular and systemic mechanistic aspects involved in the in vivo effects of PDT, with emphasis on apoptosis and autophagy induction in tumoral cells, local vascular destruction and immune response alteration. [ABSTRACT FROM AUTHOR]