1. The Hidden Role of Hydrogen Sulfide Metabolism in Cancer.
- Author
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Wang, Rong-Hsuan, Chu, Yu-Hsin, and Lin, Kai-Ti
- Subjects
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HYDROGEN sulfide , *CANCER invasiveness , *ENZYME metabolism , *METABOLISM , *CANCER treatment , *VASODILATION , *NEOVASCULARIZATION - Abstract
Hydrogen Sulfide (H2S), an endogenously produced gasotransmitter, is involved in various important physiological and disease conditions, including vasodilation, stimulation of cellular bioenergetics, anti-inflammation, and pro-angiogenesis. In cancer, aberrant up-regulation of H2S-producing enzymes is frequently observed in different cancer types. The recognition that tumor-derived H2S plays various roles during cancer development reveals opportunities to target H2S-mediated signaling pathways in cancer therapy. In this review, we will focus on the mechanism of H2S-mediated protein persulfidation and the detailed information about the dysregulation of H2S-producing enzymes and metabolism in different cancer types. We will also provide an update on mechanisms of H2S-mediated cancer progression and summarize current options to modulate H2S production for cancer therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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