1. Is Candida albicans a contributor to cancer? A critical review based on the current evidence.
- Author
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Wang X, Zhang W, Wu W, Wu S, Young A, and Yan Z
- Subjects
- Animals, Candida albicans, Inflammation, Tumor Microenvironment, Neoplasms, Candidiasis
- Abstract
The association between Candida albicans (C. albicans) and cancer has been noticed for decades. Whether C. albicans infection is a complication of cancer status or as a contributor to cancer development remains to be discussed. This review systematically summarized the up-to-date knowledge about associations between C. albicans and various types of cancer, and discussed the role of C. albicans in cancer development. Most of the current clinical and animal evidence support the relationship between C. albicans and oral cancer development. However, there is insufficient evidence to demonstrate the role of C. albicans in other types of cancer. Moreover, this review explored the underlying mechanisms for C. albicans promoting cancer. It was hypothesized that C. albicans may promote cancer progression by producing carcinogenic metabolites, inducing chronic inflammation, remodeling immune microenvironment, activating pro-cancer signals, and synergizing with bacteria., Competing Interests: Conflict of interest The authors declare no conflicts of interest with respect to the authorship and/or publication of this article., (Copyright © 2023 Elsevier GmbH. All rights reserved.)
- Published
- 2023
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