1. The human CMV-UL86 peptide 981-1003 shares a crossreactive T-cell epitope with the encephalitogenic MOG peptide 34-56, but lacks the capacity to induce EAE in rhesus monkeys.
- Author
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Brok HP, Boven L, van Meurs M, Kerlero de Rosbo N, Celebi-Paul L, Kap YS, Jagessar A, Hintzen RQ, Keir G, Bajramovic J, Ben-Nun A, Bauer J, Laman JD, Amor S, and 't Hart BA
- Subjects
- Animals, Antibodies blood, Brain pathology, CD4-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes immunology, Capsid Proteins pharmacology, Cell Line, Cell Proliferation drug effects, Cholesterol immunology, Cross Reactions, Encephalomyelitis, Autoimmune, Experimental pathology, Encephalomyelitis, Autoimmune, Experimental physiopathology, Female, Humans, Lymphocyte Activation, Male, Monocytes pathology, Myelin Proteins, Myelin-Associated Glycoprotein immunology, Myelin-Associated Glycoprotein pharmacology, Myelin-Oligodendrocyte Glycoprotein, Peptide Fragments pharmacology, Polyethylene Glycols, Recombinant Proteins immunology, Spinal Cord pathology, Capsid Proteins immunology, Cholesterol analogs & derivatives, Encephalomyelitis, Autoimmune, Experimental immunology, Epitopes, T-Lymphocyte immunology, Glycoproteins immunology, Macaca mulatta immunology, Peptide Fragments immunology
- Abstract
Rhesus monkeys immunized with MOG(34-56), a dominant T-cell epitope from myelin/oligodendrocyte glycoprotein, develop an acute neurological disease resembling acute disseminated encephalomyelitis (ADEM) in humans. The typical large demyelinated lesions and mononuclear infiltrates in the monkey brains are caused by MOG(34-56) T-cells. We show that MOG(34-56)-reactive CD4+ and CD8+ T-cells are induced in monkeys immunized with a peptide from the human CMV major capsid protein (UL86; 981-1003), that shares sequence similarity with MOG(34-56). Monkeys sensitized against the viral peptide and subsequently challenged with MOG(34-56) display histological signs of encephalitis, but do not show overt neurological signs.
- Published
- 2007
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