1. Remote Hydroxylation through Radical Translocation and Polar Crossover.
- Author
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Hollister, Kyle A., Conner, Elizabeth S., Spell, Mark L., Deveaux, Kristina, Maneval, Léa, Beal, Michael W., and Ragains, Justin R.
- Subjects
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HYDROXYLATION , *CHEMICAL reactions , *CARBOCATIONS , *NUCLEOPHILIC addition (Chemistry) , *NUCLEOPHILIC reactions , *ANTIDEPRESSANTS , *FLUOXETINE - Abstract
Mild conditions are reported for the hydroxylation of aliphatic CH bonds through radical translocation, oxidation to carbocation, and nucleophilic trapping with H2O. This remote functionalization employs fac-[Ir(ppy)3] together with Tz o sulfonate esters and sulfonamides to facilitate the site-selective replacement of relatively inert CH bonds with the more synthetically useful COH group. The hydroxylation of a range of substrates and the methoxylation of two substrates through 1,6- and 1,7-hydrogen-atom transfer are demonstrated. In addition, a synthesis of the antidepressant fluoxetine using remote hydroxylation as a key step is presented. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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