1. Effects of Magnetic Field Applied Just Before, During or Immediately after Carbon-Ion Beam Irradiation on its Biological Effectiveness.
- Author
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Inaniwa T, Suzuki M, Sato S, Muramatsu M, Mizushima K, Iwata Y, Kanematsu N, Shirai T, and Noda K
- Subjects
- Calibration, Cell Line, Tumor, DNA Damage, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Humans, Ions, Relative Biological Effectiveness, Reproducibility of Results, Carbon chemistry, Cell Survival radiation effects, Heavy Ion Radiotherapy methods, Heavy Ions, Linear Energy Transfer, Magnetic Fields
- Abstract
Previously reported studies have revealed that the application of a magnetic field longitudinal to a carbon-ion beam enhances its biological effectiveness. Here we investigated how timing of the magnetic field application with respect to beam irradiation influenced this effect. Human cancer cells were exposed to carbon-ion beams with linear energy transfer (LET) of 12 and 50 keV/µm. The longitudinal magnetic field of 0.3 T was applied to the cells just before, during or immediately after the beam irradiation. The effects of the timing on the biological effectiveness were evaluated by cell survival. The biological effectiveness increased only if the magnetic field was applied during beam irradiation for both LETs.
- Published
- 2019
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