1. Inhibitors of CA IX Enzyme Based on Polyhedral Boron Compounds.
- Author
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Kugler M, Nekvinda J, Holub J, El Anwar S, Das V, Šícha V, Pospíšilová K, Fábry M, Král V, Brynda J, Kašička V, Hajdúch M, Řezáčová P, and Grüner B
- Subjects
- Binding Sites, Boron Compounds metabolism, Boron Compounds therapeutic use, Carbonic Anhydrase IX metabolism, Carbonic Anhydrase Inhibitors chemical synthesis, Carbonic Anhydrase Inhibitors metabolism, Carbonic Anhydrase Inhibitors therapeutic use, Humans, Molecular Dynamics Simulation, Neoplasms drug therapy, Organometallic Compounds chemistry, Structure-Activity Relationship, Sulfonamides chemistry, Boron Compounds chemistry, Carbonic Anhydrase IX antagonists & inhibitors, Carbonic Anhydrase Inhibitors chemistry
- Abstract
This review describes recent progress in the design and development of inhibitors of human carbonic anhydrase IX (CA IX) based on space-filling carborane and cobalt bis(dicarbollide) clusters. CA IX enzyme is known to play a crucial role in cancer cell proliferation and metastases. The new class of potent and selective CA IX inhibitors combines the structural motif of a bulky inorganic cluster with an alkylsulfamido or alkylsulfonamido anchor group for Zn
2+ ion in the enzyme active site. Detailed structure-activity relationship (SAR) studies of a large series containing 50 compounds uncovered structural features of the cluster-containing inhibitors that are important for efficient and selective inhibition of CA IX activity. Preclinical evaluation of selected compounds revealed low toxicity, favorable pharmacokinetics and ability to reduce tumor growth. Cluster-containing inhibitors of CA IX can thus be considered as promising candidates for drug development and/or for combination therapy in boron neutron capture therapy (BNCT)., (© 2021 Wiley-VCH GmbH.)- Published
- 2021
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