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Your search keyword '"Sundarababu, Gajendran"' showing total 1 results
Start Over Author "Sundarababu, Gajendran" Topic carbonyl compounds -- research
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1. Asymmetric fluorination of enolates with nonracemic N-fluoro-2,10-camphorsultams

Author

Davis, Franklin A., Zhou, Ping, Murphy, Christopher K., Sundarababu, Gajendran, Qi, Hongyan, Han, Wei, Przeslawski, Robert M., Chen, Bang-Chi, and Carroll, Patrick J.

Subjects
Fluorination -- Research, Carbonyl compounds -- Research, Biological sciences, Chemistry
Abstract

Quaternary alpha-fluoro carbonyl compounds were produced from electrophilic asymmetric fluorination of tertiary enolates by N-fluoro-2,10-camphorsultams in moderate yield and enatiomeric excess. These reagents displayed a sense of asymmetric induction that is in contrast with that for (camphorylsulfonyl)oxaziridine hydroxylating reagents, a closely related compound. The fluorination of the sodium enolate of 2-methyl-1-tetralone by (-)-N-fluoro-2,10-(3,3-dichlorocamphorsusltam) exhibited the highest asymmetric induction.

Published
1998

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