1. Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae).
- Author
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Waleguele CC, Mba'ning BM, Awantu AF, Bankeu JJK, Fongang YSF, Ngouela AS, Tsamo E, Sewald N, Lenta BN, and Krause RWM
- Subjects
- Cell Survival drug effects, Chloroquine pharmacology, Inhibitory Concentration 50, Magnetic Resonance Spectroscopy, Mass Spectrometry, Microbial Sensitivity Tests, Molecular Structure, Plant Leaves chemistry, Plant Roots chemistry, Plasmodium falciparum drug effects, Trypanosoma brucei brucei drug effects, Anti-Infective Agents analysis, Antimalarials pharmacology, Antiparasitic Agents pharmacology, Carboxylic Acids chemistry, Lauraceae chemistry, Plant Extracts chemistry, Plant Extracts pharmacology
- Abstract
The MeOH/CH
2 Cl2 (1:1) extracts of the roots and leaves of Beilschmiedia louisii and B. obscura showed potent antitrypanosomal activity during preliminary screening on Trypanosoma brucei brucei . Phytochemical investigation of these extracts led to the isolation of a mixture of two new endiandric acid derivatives beilschmiedol B ( 1 ) and beilschmiedol C ( 2 ), and one new phenylalkene obscurene A ( 3 ) together with twelve known compounds ( 4 - 15 ). In addition, four new derivatives ( 11a - 11d ) were synthesized from compound 11 . Their structures were elucidated based on their NMR and MS data. Compounds 5 , 6 , and 7 were isolated for the first time from the Beilschmiedia genus. Additionally, the NMR data of compound 4 are given here for the first time. The isolates were evaluated for their antitrypanosomal and antimalarial activities against Tb brucei and the Plasmodium falciparum chloroquine-resistant strain Pf3D7 in vitro, respectively. From the tested compounds, the mixture of new compounds 1 and 2 exhibited the most potent antitrypanosomal activity in vitro with IC50 value of 4.91 μM.- Published
- 2020
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