1. Ni-electrocatalytic Csp 3 -Csp 3 doubly decarboxylative coupling.
- Author
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Zhang B, Gao Y, Hioki Y, Oderinde MS, Qiao JX, Rodriguez KX, Zhang HJ, Kawamata Y, and Baran PS
- Subjects
- Catalysis, Decarboxylation, Electrochemistry, Esters chemistry, Molecular Structure, Oxidation-Reduction, Carboxylic Acids chemistry, Chemistry Techniques, Synthetic, Nickel chemistry
- Abstract
Cross-coupling between two similar or identical functional groups to form a new C-C bond is a powerful tool to rapidly assemble complex molecules from readily available building units, as seen with olefin cross-metathesis or various types of cross-electrophile coupling
1,2 . The Kolbe electrolysis involves the oxidative electrochemical decarboxylation of alkyl carboxylic acids to their corresponding radical species followed by recombination to generate a new C-C bond3-12 . As one of the oldest known Csp3 -Csp3 bond-forming reactions, it holds incredible promise for organic synthesis, yet its use has been almost non-existent. From the perspective of synthesis design, this transformation could allow one to agnostically execute syntheses without regard to polarity or neighbouring functionality just by coupling ubiquitous carboxylates13 . In practice, this promise is undermined by the strongly oxidative electrolytic protocol used traditionally since the nineteenth century5 , thereby severely limiting its scope. Here, we show how a mildly reductive Ni-electrocatalytic system can couple two different carboxylates by means of in situ generated redox-active esters, termed doubly decarboxylative cross-coupling. This operationally simple method can be used to heterocouple primary, secondary and even certain tertiary redox-active esters, thereby opening up a powerful new approach for synthesis. The reaction, which cannot be mimicked using stoichiometric metal reductants or photochemical conditions, tolerates a range of functional groups, is scalable and is used for the synthesis of 32 known compounds, reducing overall step counts by 73%., (© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)- Published
- 2022
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