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Start Over Author "Bower JJ" Topic carcinogens
2 results on '"Bower JJ"'

1. Conference overview: molecular mechanisms of metal toxicity and carcinogenesis.

Author

Bower JJ, Leonard SS, and Shi X

Subjects
Animals, Antioxidants metabolism, Arsenic toxicity, Biliary Tract Neoplasms metabolism, Biomarkers, Tumor blood, Carcinogenicity Tests, Chromium toxicity, Copper toxicity, DNA Damage, Environmental Exposure, Humans, Mitosis drug effects, Models, Animal, Mouth Neoplasms blood, Mouth Neoplasms metabolism, Reactive Oxygen Species metabolism, Signal Transduction drug effects, Biliary Tract Neoplasms chemically induced, Carcinogens toxicity, Metals toxicity, Mouth Neoplasms chemically induced
Abstract

Chronic exposure to many heavy metals and metal-derivatives is associated with an increased risk of cancer, although the mechanisms of tumorigenesis are largely unknown. Approximately 125 scientists attended the 3rd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis and presented the latest research concerning these mechanisms. Major areas of focus included exposure assessment and biomarker identification, roles of ROS and antioxidants in carcinogenesis, mechanisms of metal-induced DNA damage, metal signalling, and the development of animal models for use in metal toxicology studies. Here we highlight some of the research presented, and summarize the conference proceedings.

Published
2005
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2. Metal-induced toxicity, carcinogenesis, mechanisms and cellular responses.

Author

Leonard SS, Bower JJ, and Shi X

Subjects
Animals, Apoptosis drug effects, Cell Cycle drug effects, Cell Division drug effects, DNA Adducts metabolism, DNA Damage, DNA Repair, Free Radicals metabolism, Gene Expression drug effects, Humans, Metals metabolism, Mice, Neoplasms chemically induced, Reactive Oxygen Species metabolism, Signal Transduction drug effects, Transcription Factors drug effects, Transcription Factors physiology, Carcinogens toxicity, Cell Transformation, Neoplastic chemically induced, Metals toxicity, Mutagens toxicity
Abstract

A wide variety of metals have been reported to act as mutagenic and carcinogenic agents in both human and animal studies. The underlying mechanisms are being extensively investigated. Recently, a new sub-discipline of molecular carcinogenesis has surfaced and new techniques and instruments are being developed which allow exploration of the complex biological relationships and signaling pathways involved in response to metal exposure at the molecular level. The 2nd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis was held at NIOSH in Morgantown, West Virginia, Sept. 8-11, 2002. One hundred thirty scientist from sixteen countries presented their novel findings and investigations of metal-induced carcinogenesis. The conference focused on state-of-the-art research and developments in metal toxicity and carcinogenesis. Emphasis was placed on delineating molecular mechanisms involved in free radical effects, cellular uptake, signaling pathways/interaction, dose response, biomarkers, and resistance mechanisms. This article reviews some of the novel information presented at the conference and discusses future avenues of research in this field.

Published
2004
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