1. Visible near infrared reflectance molecular chemical imaging of human ex vivo carcinomas and murine in vivo carcinomas
- Author
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Shona Stewart, Jeffrey Cohen, Arash Samiei, Aaron Smith, James C. Post, Patrick J. Treado, John Lyne, Ralph Miller, Marlena Darr, and Heather Gomer
- Subjects
Pathology ,intraoperative imaging ,Lung Neoplasms ,hyperspectral imaging ,Mice, SCID ,01 natural sciences ,Imaging ,surgery ,Mice ,Mice, Inbred NOD ,Image Processing, Computer-Assisted ,Medicine ,Carcinoma, Ductal, Breast ,kidney cancer ,Discriminant Analysis ,Atomic and Molecular Physics, and Optics ,Kidney Neoplasms ,Electronic, Optical and Magnetic Materials ,Heterografts ,Preclinical imaging ,Paper ,medicine.medical_specialty ,Infrared Rays ,renal cancer ,Biomedical Engineering ,Breast Neoplasms ,Adenocarcinoma ,Sensitivity and Specificity ,010309 optics ,Biomaterials ,Breast cancer ,breast cancer ,molecular chemical imaging ,In vivo ,Computer Systems ,0103 physical sciences ,Animals ,Humans ,Lung cancer ,Carcinoma, Renal Cell ,Carcinoma, Transitional Cell ,Receiver operating characteristic ,business.industry ,Cancer ,Reproducibility of Results ,medicine.disease ,lung cancer ,Disease Models, Animal ,ROC Curve ,business ,Kidney cancer ,Ex vivo - Abstract
Significance: A key risk faced by oncological surgeons continues to be complete removal of tumor. Currently, there is no intraoperative imaging device to detect kidney tumors during excision. Aim: We are evaluating molecular chemical imaging (MCI) as a technology for real-time tumor detection and margin assessment during tumor removal surgeries. Approach: In exploratory studies, we evaluate visible near infrared (Vis-NIR) MCI for differentiating tumor from adjacent tissue in ex vivo human kidney specimens, and in anaesthetized mice with breast or lung tumor xenografts. Differentiation of tumor from nontumor tissues is made possible with diffuse reflectance spectroscopic signatures and hyperspectral imaging technology. Tumor detection is achieved by score image generation to localize the tumor, followed by application of computer vision algorithms to define tumor border. Results: Performance of a partial least squares discriminant analysis (PLS-DA) model for kidney tumor in a 22-patient study is 0.96 for area under the receiver operating characteristic curve. A PLS-DA model for in vivo breast and lung tumor xenografts performs with 100% sensitivity, 83% specificity, and 89% accuracy. Conclusion: Detection of cancer in surgically resected human kidney tissues is demonstrated ex vivo with Vis-NIR MCI, and in vivo on mice with breast or lung xenografts.
- Published
- 2020