1. Hepatic resection and percutaneous ethanol injection as treatments of small hepatocellular carcinoma: a Cancer of the Liver Italian Program (CLIP 08) retrospective case-control study
- Author
-
Ciro Gallo, Paolo Vallone, Francesco Perrone, G.B. Gaeta, A. Andreana, Gaetano Capuano, Antonino Aiello, Francesco Izzo, Roberto Mazzanti, Ilario de Sio, Sandro Pignata, Francesco Fiore, Bruno Daniele, Daniele, B, DE SIO, I, Izzo, F, Capuano, G, Andreana, A, Mazzanti, R, Aiello, A, Vallone, P, Fiore, F, Gaeta, Giovanni Battista, Perrone, F, Pignata, S, and Gallo, Ciro
- Subjects
Surgical resection ,Male ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Hepatic resection ,medicine.medical_treatment ,macromolecular substances ,Injections, Intralesional ,Gastroenterology ,Internal medicine ,medicine ,Carcinoma ,Hepatectomy ,Humans ,Aged ,Proportional Hazards Models ,Ethanol ,business.industry ,Liver Neoplasms ,technology, industry, and agriculture ,Case-control study ,Cancer ,Middle Aged ,medicine.disease ,digestive system diseases ,Surgery ,Hepatocellular carcinoma ,Case-Control Studies ,Female ,Percutaneous ethanol injection ,business - Abstract
Patients with small hepatocellular carcinoma (HCC) are usually treated with hepatic resection or percutaneous ethanol injection (PEI).To compare the effects of hepatic resection versus PEI on survival in a matched case-control study. STUDY Patients with single-nodule HCC (or=5 cm) who were treated with hepatic resection (cases) or PEI (controls) were eligible. Matching criteria were date of diagnosis, Child-Pugh stage, and age at diagnosis. Kaplan-Meier survival curve of the control group was drawn weighing each stratum by the inverse of its size. Treatments were compared by a stratified Cox's model, adjusted by CLIP score.Of 912 patients, 197 were eligible and 82 (17 cases and 65 controls) were matched, creating 17 strata. Nine (53%) cases and 41 (63%) controls died. Cox model showed no survival difference between the two groups; hazard ratio of PEI versus hepatic resection was 1.04 (95% CI = 0.43-2.52). One- and 3-year survival rates in the hepatic resection and PEI groups were 82% versus 91% and 63% versus 65%, respectively.Patients with small HCC treated with hepatic resection or PEI have similar survival rates. In view of the higher cost and morbidity of hepatic resection, a prospective randomized study is warranted.
- Published
- 2002