1. Combined Hepatocellular-Cholangiocarcinoma With Ductal Plate Malformation Pattern: A Case Report With Molecular Analysis.
- Author
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Moon WS, Song JS, Yu HC, Kim KM, and Ahn AR
- Subjects
- Male, Humans, Middle Aged, Bile Ducts, Intrahepatic pathology, p120 GTPase Activating Protein, Carcinoma, Hepatocellular diagnosis, Carcinoma, Hepatocellular genetics, Carcinoma, Hepatocellular surgery, Liver Neoplasms diagnosis, Liver Neoplasms genetics, Liver Neoplasms pathology, Cholangiocarcinoma genetics, Cholangiocarcinoma surgery, Cholangiocarcinoma pathology, Bile Duct Neoplasms genetics, Bile Duct Neoplasms surgery, Bile Duct Neoplasms pathology
- Abstract
Combined hepatocellular-cholangiocarcinoma with a ductal plate malformation pattern is an extremely rare entity with unelucidated pathogenesis. We present the case of a 60-year-old male patient who underwent a sectionectomy for pre-operative diagnosis of hepatocellular carcinoma based on clinical and image findings. Gross examination of the specimen revealed a well-defined tumor with cystic change measuring 6.7 × 6.2 cm. Microscopically, the lesion had classical features of hepatocellular carcinoma and intrahepatic cholangiocarcinoma exhibited neoplastic glands with irregular-sized dilated lumens, resembling a ductal plate malformation. Postoperative diagnosis was combined hepatocellular-cholangiocarcinoma with ductal plate malformation pattern. Next-generation sequencing revealed genomic alteration in 15 genes: CDKN2A , CHD4 , CYP2D6 , ERBB3 , KIR3DL1 , KRAS , MDM2 , PIM1 , STAT6 , TPMT amplification, FANCD2 , FAT1 , FLT4 , RASA1 , and TP53 point mutation. This is the first case report of molecular alteration in combined hepatocellular-cholangiocarcinoma with ductal plate malformation pattern., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
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