1. p16INK4A expression is frequently increased in periorbital and ocular squamous lesions.
- Author
-
Kobalka, Peter J, Abboud, Jean-Paul, Liao, Xiaoyan, Jones, Karra, Lee, Bradford W, Korn, Bobby S, Kikkawa, Don O, and Lin, Jonathan H
- Subjects
Humans ,Carcinoma ,Squamous Cell ,Eye Neoplasms ,Retrospective Studies ,Gene Expression Regulation ,Neoplastic ,Genes ,p16 ,Adult ,Aged ,Aged ,80 and over ,Middle Aged ,Female ,Male ,Biomarkers ,Tumor ,Carcinoma ,Squamous Cell ,Gene Expression Regulation ,Neoplastic ,Genes ,p16 ,and over ,Biomarkers ,Tumor ,Rare Diseases ,Infectious Diseases ,Cancer ,Dental/Oral and Craniofacial Disease ,Digestive Diseases ,Clinical Research ,Sexually Transmitted Infections ,4.1 Discovery and preclinical testing of markers and technologies ,2.1 Biological and endogenous factors ,Pathology - Abstract
Backgroundp16 expression is a well established biomarker of cervical dysplasia and carcinoma arising from high risk human papilloma virus infection. Increased p16 expression is also seen in squamous neoplasms arising at other sites, including head, neck, and oropharyngeal tract. Squamous lesions are also frequently encountered at ocular surface and peri-orbital skin sites, but the prevalence of increased p16 expression in these lesions has been poorly studied.MethodsWe retrospectively surveyed 13 ocular surface and 16 orbital squamous lesions biopsied at UC San Diego Healthcare System and VA San Diego Healthcare System for p16 expression by immunohistochemistry. These cases included ocular surface lesions with diagnoses of conjunctival intraepithelial neoplasm (CIN) and squamous cell carcinoma in situ. Peri-orbital eyelid biopsies included lesions with diagnoses of SCCis and invasive squamous cell carcinoma. We performed multivariate logistic regression, followed by student's T-test or Fisher's exact test to determine if there were statistically significant associations between p16 immunoreactivity and patient age, gender, diagnosis, and ethnicity. Statistical significance was defined as p
- Published
- 2015