1. Nasopharyngeal carcinoma in children.
- Author
-
Roper HP, Essex-Cater A, Marsden HB, Dixon PF, and Campbell RH
- Subjects
- Adolescent, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma drug therapy, Carcinoma pathology, Carcinoma radiotherapy, Child, Combined Modality Therapy, Cyclophosphamide administration & dosage, Doxorubicin administration & dosage, Female, Humans, Male, Methotrexate administration & dosage, Nasopharyngeal Neoplasms drug therapy, Nasopharyngeal Neoplasms pathology, Nasopharyngeal Neoplasms radiotherapy, Retrospective Studies, Sex Factors, United Kingdom epidemiology, Carcinoma mortality, Nasopharyngeal Neoplasms mortality
- Abstract
The results of treatment are reviewed in 18 cases of childhood nasopharyngeal carcinoma. Since 1976 adjuvant chemotherapy with cyclophosphamide, methotrexate, and adriamycin has been used in Manchester and Leeds. The outcome is compared in 9 patients treated with radiotherapy alone and 9 patients treated later with both radiotherapy and adjuvant chemotherapy. Relapse-free survival rates were 0% for those treated with radiotherapy alone and 78% at 13-80 months after diagnosis for those treated with both radiotherapy and chemotherapy. It is concluded that adjuvant chemotherapy improves relapse-free survival in childhood nasopharyngeal carcinoma.
- Published
- 1986
- Full Text
- View/download PDF