5 results on '"Baufreton C"'
Search Results
2. Enquête nationale sur l’assistance circulatoire et respiratoire de courte durée en 2009
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Baufreton, C., Brochet, A., Darrieutort, H., Chrétien, J.-M., Parot Schinkel, E., Tanguy, M., Dalmayrac, E., and Lehot, J.-J.
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CARDIAC surgery , *PERFUSION , *QUESTIONNAIRES , *SURVEYS , *CARDIOVASCULAR diseases , *BIOINDICATORS - Abstract
Abstract: Objective: Indications for short-term circulatory and/or respiratory support (STCRS) increased during the last years. The goal of this survey was to characterize this activity in France in 2009. Study design: Observational retrospective pluricentral. Materiel and methods: Each center of cardiothoracic surgery received a questionnaire validated by the Société française de perfusion about the activity, materials and organization used for STCRS. Data were expressed as percentages or median (25–75 percentiles). Results: Forty-one centers on 61 (67%) answered. STCRS was performed respectively by 33 (80.5 %), 36 (87.8 %) and 39 (95.1 %) of centers in 2007, 2008 and 2009 including 10 [4–26], 18 [6–29] and 18 [5–33] cases/center per year. In 2009, types of STCRS installed were veno-arterial in 39 centres (95.1 %), veno-venous in 27 (65.9 %) and Novalung® in four (9.8 %), including 18 [5–32], five [2–7] and 15 [1–17] cases respectively. Twenty-nine centers (70.7%) installed STCRS outside the operating theater, and 24 (58.5%) in non-cardiothoracic surgery. A mobile circulatory support unit was created in eight centers (19.5%), however 21 (51.2%) have installed STCRS externally, at distances between 10 [5–55] to 100 [15–200] km, using emergency vehicles in most of the cases (90.5%), but helicopter seldom (19%). Conclusion: STCRS has increased over the last few years in France. Externalized activity outside the operating theater was important, time-consuming and used hospital resources therefore modifying the professional activity of perfusionists. [Copyright &y& Elsevier]
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- 2013
- Full Text
- View/download PDF
3. Réponse inflammatoire et perturbations hématologiques en chirurgie cardiaque : vers une circulation extracorporelle plus physiologique
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Baufreton, C., Corbeau, J.-J., and Pinaud, F.
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CARDIOPULMONARY bypass , *CARDIAC surgery , *SPLANCHNIC nerves , *HEMOSTASIS - Abstract
Abstract: The systemic inflammatory response in cardiac surgery is closely related to the haemostasis disturbances. It is responsible of a significant morbidity and mortality that was previously suspected to be caused by cardiopulmonary bypass alone. However, it is time now to clearly identify the factors that are material-dependent from that material-independent. From this point of view, off-pump surgery allowed for better comprehension of the multiple sources of the inflammatory response. Numerous pathways are activated, involving complement, platelets, neutrophiles and monocytes. The tissue pathway of the coagulation system, through tissue factor, is of major importance and has to be surgically considered in order to reduce the whole body inflammatory response postoperatively. The quality of the extracorporeal perfusion through its consequences on organ perfusion, particularly in the splanchnic area, also participates to this pathophysiological process. Beyond the progress of technology provided by the industry, particularly the minimally extracorporeal circulation derived from off-pump surgery evolution, the surgical approach is of major importance in the control of the systemic inflammatory response and must not be ignored yet. [Copyright &y& Elsevier]
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- 2006
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4. Incidence et évolution des images thrombotiques dans la veine jugulaire interne après cathétérisme de Swan-Ganz en chirurgie cardiaque
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Jeanneteau, J., Braud, O., Pinaud, F., Faraj, S., Gillet, S., Cottineau, C., de Brux, J.-L., and Baufreton, C.
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CARDIAC surgery , *JUGULAR vein , *BLOOD vessels , *CARDIOVASCULAR system , *ANGIOSPASM - Abstract
Abstract: Objectives: Insertion of Swan-Ganz catheter for a few days may be necessary in cardiac surgery. This study was aimed at determining the incidence and the evolution of thrombotic images within the internal jugular vein as well as assessing their association with the presence of a prolonged fever at postoperative day 7 in the lack of any documented infection. Material and methods: All the patients undergoing cardiac surgery had a two-dimensional ultrasonography of internal jugular veins preoperatively, at discharge (day 7) and at postoperative day 90 if thrombotic images were seen at day 7. Results: Sleeve-like and compact thrombotic images have been observed in site of venipuncture in 52 patients (70.3%). None had any residual thrombotic image 90 days after the operation. No clinical thromboembolic migration has been observed. There was no statistical association between the presence of a thrombotic image at the ultrasonography and the duration of catheterization. Moreover, there was no association between the anticoagulation before, during and after the surgery and the presence of a thrombotic image. We found a non-significant association between fever at day 7 and the presence of a thrombotic image within the internal jugular vein. Conclusion: Thrombotic images in the internal jugular vein after catheterization are frequent and disappear at day 90. The limited sample size of this study does not provide strong evidence of the role of jugular thrombi in the prolongation of fever after cardiac surgery. [Copyright &y& Elsevier]
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- 2009
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5. Protection of the microcirculation during cardiac surgery with cardiopulmonary bypass
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Koning, NJ, Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université d'Angers, Vrije universiteit (Amsterdam), Christophe Baufreton, Boer, Christa, Baufreton, Christophe, Vonk, Alexander, van Nieuw Amerongen, Geerten, Anesthesiology, ACS - Microcirculation, Boer, C., Baufreton, C., Vonk, A.B.A., and van Nieuw Amerongen, G.P.
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Inflammation ,endothelium ,Circulation extra-Corporelle ,Cardiopulmonary bypass ,Microcirculation ,Chirurgie cardiaque ,Cardiac surgery ,anesthesia ,Endothelium ,Endothélium ,cardiopulmonary bypass ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,cardiac surgery - Abstract
Cardiac surgery with cardiopulmonary bypass leads to impaired perfusion of the microcirculation, which may be an important contributor to postoperative organ dysfunction. This thesis combines clinical and animal studies that aimed to investigate the mechanisms underlying microcirculatory dysfunction in cardiac surgery with cardiopulmonary bypass. Moreover, we aimed to evaluate two treatments strategies for preservation of microcirculatory perfusion during cardiopulmonary bypass : the use of pulsatile flow as compared to the conventional non pulsatile flow during cardiopulmonary bypass and treatment with imatinib in order to reduce vascular leakage by inhibiting endothelial barrier dysfunction.The current thesis has demonstrated that microcirculatory perfusion is impaired during and after cardiac surgery, and this can be attributed mainly to inflammatory endothelial barrier dysfunction and consequent vascular leakage. Concomitant hemodilution may additionally contribute to reduced microvascular perfusion and oxygenation in on-pumpcardiac surgery. We showed that the use of pulsatile flow during cardiopulmonary bypass improves postoperative microvascular perfusion as compared to non pulsatile flow. Imatinib treatment reduced endothelial barrier dysfunction and vascular leakage in our rat model for cardiopulmonary bypass and resulted in preservation of microcirculatory perfusion andoxygenation during and after extracorporeal circulation.Moreover, imatinib treatment resulted in reduced markers ofrenal, pulmonary and intestinal injury after cardiopulmonary bypass. Based on our findings, reduction of vascular leakage and use of pulsatile flow during cardiopulmonary bypass are promising interventions for the prevention of postoperative complications in patients at risk for organ failure following cardiac surgery with cardiopulmonary bypass.; La chirurgie cardiaque sous circulation extra-corporelle conduit à une altération de la perfusion de la microcirculation, qui peut contribuer de façon importante à la dysfonction d’organe postopératoire. Cette thèse rassemble des études cliniques et animales, dont le but était d’investiguer les mécanismes expliquant la dysfonction microcirculatoire en chirurgie cardiaque sous circulation extra-corporelle. En outre nous avons eu pour but d’évaluer deux stratégies thérapeutiques pour la préservation de la perfusion microcirculatoire au cours de la circulation extracorporelle : l’utilisation d’un flux pulsé comparativement à un flux non pulsé conventionnel durant la circulation extra-corporelle, et le traitement par imatinib dans le but de réduire la fuite vasculaire en inhibant la dysfonction de la barrière endothéliale. La thèse actuelle a démontré que la perfusion microcirculatoire est altérée durant et après la chirurgie cardiaque, et que ceci peut être attribué principalement à la dysfonction inflammatoire de la barrière endothéliale et à la fuite vasculaire conséquente. L’hémodilution concomitante en chirurgie cardiaque sous circulation extra-corporelle peut s’ajouter et contribuer également à la réduction de la perfusion microcirculatoire et de l’oxygénation. Nous avons montré que l’utilisation d’un flux pulsé durant la circulation extracorporelle améliore la perfusion microcirculatoire en postopératoire comparativement à un flux non-pulsé. Le traitement par imatinib a réduit la dysfonction de la barrière endothéliale et la fuite vasculaire dans notre modèle de circulation extracorporelle sur le rat et a permis de préserver la perfusion microcirculatoire et l’oxygénation durant et après la circulation extra-corporelle. En outre, le traitement par imatinib a permis de diminuer les marqueurs de souffrance rénale, pulmonaire et digestive après circulation extra-corporelle. A partir de nos résultats, la réduction de la fuite vasculaire et l’utilisation d’un flux pulsé durant la circulation extra-corporelle sont des interventions prometteuses pour la prévention des complications postopératoires chez les patients à risque de défaillance d’organe au décours de la chirurgie cardiaque sous circulation extra-corporelle.
- Published
- 2017
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