1. Vascular Compliance Changes of the Coronary Vessel Wall After Bioresorbable Vascular Scaffold Implantation in the Treated and Adjacent Segments
- Author
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Chrysafios Girasis, van Geuns Robert Jan, Yoshinobu Onuma, Heo Jung He, Bill D. Gogas, Dariuz Dudek, Vasim Farooq, Susan Veldhof, Jacques J. Koolen, Patrick W. Serruys, de Bruyne Bernard, Salvatore Brugaletta, Pieter C. Smits, Hector M. Garcia-Garcia, Richard Rapoza, John A. Ormiston, Cardiology, and Radiology & Nuclear Medicine
- Subjects
Male ,Scaffold ,medicine.medical_specialty ,Time Factors ,Polyesters ,medicine.medical_treatment ,Coronary Artery Disease ,Coronary Angiography ,Prosthesis Design ,Prosthesis ,Predictive Value of Tests ,Internal medicine ,Coronary Circulation ,Absorbable Implants ,Humans ,Medicine ,Everolimus ,Angioplasty, Balloon, Coronary ,Ultrasonography, Interventional ,Aged ,Bioresorbable vascular scaffold ,Sirolimus ,poly-lactide ,business.industry ,Compliance mismatch ,Hemodynamics ,Cardiovascular Agents ,Drug-Eluting Stents ,General Medicine ,vascular compliance ,Middle Aged ,Coronary Vessels ,Biomechanical Phenomena ,Vascular compliance ,Surgery ,Compliance (physiology) ,Treatment Outcome ,Coronary vessel ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,ABSORB ,Paired Analysis ,Compliance ,Biomedical engineering - Abstract
Background: Implantation of a metallic prosthesis creates local stiffness with a subsequent mismatch in the compliance of the vessel wall, disturbances in flow and heterogeneous distribution of wall shear stress. Polymeric bioresorbable ABSORB scaffolds have less stiffness than metallic platform stents. We sought to analyze the mismatch in vascular compliance after ABSORB implantation and its long-term resolution with bioresorption. Methods and Results: A total of 83 patients from the ABSORB trials underwent palpography investigations (30 and 53 patients from ABSORB Cohorts A and B, respectively) to measure the compliance of the scaffolded and adjacent segments at various time points (from pre-implantation up to 24 months). The mean of the maximum strain values was calculated per segment by utilizing the Rotterdam Classification (ROC) score and expressed as ROC/ mm. Scaffold implantation lead to a significant decrease in vascular compliance (median [IQR]) at the scaffolded segment (from 0.37 [0.24-0.45] to 0.14 [0.09-0.23], P
- Published
- 2012
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