1. Orientation of the right superior pulmonary vein affects outcome after pulmonary vein isolation
- Author
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István Osztheimer, Pál Maurovich-Horvat, Bálint Szilveszter, Hana Idelbi, Nándor Szegedi, Szilvia Herczeg, Milán Vecsey-Nagy, Vivien Klaudia Nagy, Béla Merkely, Jeroen J. Bax, László Gellér, Gábor Széplaki, Judit Simon, Márton Kolossváry, Tamás Tahin, and Victoria Delgado
- Subjects
medicine.medical_specialty ,Multivariate analysis ,Radiofrequency ablation ,030204 cardiovascular system & hematology ,030218 nuclear medicine & medical imaging ,Pulmonary vein ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,Orientation (mental) ,law ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Retrospective Studies ,Computed tomography angiography ,Univariate analysis ,medicine.diagnostic_test ,business.industry ,Atrial fibrillation ,General Medicine ,Odds ratio ,medicine.disease ,Treatment Outcome ,Pulmonary Veins ,Catheter Ablation ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Aims Controversial results have been published regarding the influence of pulmonary vein (PV) anatomical variations on outcomes after pulmonary vein isolation (PVI). However, no data are available on the impact of PV orientation on the long-term success rates of point-by-point PVI. We sought to determine the impact of PV anatomy and orientation on atrial fibrillation (AF)-free survival in patients undergoing PVI using the radiofrequency point-by-point technique. Methods and results We retrospectively included 448 patients who underwent initial point-by-point radiofrequency ablation for AF at our department. Left atrial computed tomography angiography was performed before each procedure. PV anatomical variations, ostial parameters (area, effective diameter, and eccentricity), orientation, and their associations with 24-month AF-free survival were analysed. PV anatomical variations and ostial parameters were not predictive for AF-free survival (all P > 0.05). Univariate analysis showed that female sex (P = 0.025) was associated with higher rates of AF recurrence, ventral-caudal (P = 0.002), dorsal-cranial (P = 0.034), and dorsal-caudal (P = 0.042) orientation of the right superior PV (RSPV), on the other hand, showed an association with lower rates of AF recurrence, when compared with the reference ventral-cranial orientation. On multivariate analysis, both female sex [odds ratio (OR) 1.83, 95% CI 1.15–2.93, P = 0.011] and ventral-caudal RSPV orientation, compared with ventral-cranial orientation, proved to be independent predictors of 24-month AF recurrence (OR 0.37, 95% CI 0.19–0.71, P = 0.003). Conclusion Female sex and ventral-caudal RSPV orientation have an impact on long-term arrhythmia-free survival. Assessment of PV orientation may be a useful tool in predicting AF-free survival and may contribute to a more personalized management of AF.
- Published
- 2021
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