1. Association of obstructive sleep apnea with arterial stiffness and nondipping blood pressure in patients with hypertension
- Author
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Elias Marum, Heno Ferreira Lopes, Luciano F. Drager, Fernanda Fatureto-Borges, Sandra H. Teixeira, Raimundo Jenner, Eduardo M. Krieger, Luiz Aparecido Bortolotto, Dante A.M. Giorgi, Valeria Costa-Hong, Fernanda Marciano Consolim-Colombo, and Geraldo Lorenzi-Filho
- Subjects
Male ,Endocrinology, Diabetes and Metabolism ,Angiotensin-Converting Enzyme Inhibitors ,Blood Pressure ,Polysomnography ,030204 cardiovascular system & hematology ,0302 clinical medicine ,Hydrochlorothiazide ,Enalapril ,Risk Factors ,Sleep Apnea and Hypertension ,030212 general & internal medicine ,Diuretics ,Pulse wave velocity ,Sleep Apnea, Obstructive ,medicine.diagnostic_test ,Sleep apnea ,SEXO ,Blood Pressure Monitoring, Ambulatory ,Middle Aged ,Cardiovascular Diseases ,Echocardiography ,Hypertension ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,Brazil ,medicine.drug ,Adult ,medicine.medical_specialty ,Ambulatory blood pressure ,Pulse Wave Analysis ,Losartan ,03 medical and health sciences ,Vascular Stiffness ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Aged ,business.industry ,medicine.disease ,respiratory tract diseases ,Obstructive sleep apnea ,Blood pressure ,Arterial stiffness ,business ,Angiotensin II Type 1 Receptor Blockers - Abstract
Whether sex influences the association of obstructive sleep apnea (OSA) with markers of cardiovascular risk in patients with hypertension is unknown. In this study, 95 hypertensive participants underwent carotid-femoral pulse wave velocity, 24-hour ambulatory blood pressure monitoring, echocardiogram, and polysomnography after a 30-day standardized treatment with hydrochlorothiazide plus enalapril or losartan. OSA was present in 52 patients. Compared with non-OSA patients, pulse wave velocity values were higher in the OSA group (men: 11.1±2.2 vs 12.7±2.4 m/s, P=.04; women: 11.8±2.4 vs 13.2±2.2 m/s, P=.03). The proportion of diastolic dysfunction was significant in men and women with OSA. Compared with non-OSA patients, nondipping systolic blood pressure in OSA was higher in men (14.3% vs 46.4%) and in women (41.4% vs 65.2%). OSA was independently associated with pulse wave velocity (β=1.050; P=.025) and nondipping systolic blood pressure (odds ratio, 3.03; 95% confidence interval, 1.08-8.55; P=.035) in the regression analysis. In conclusion, OSA is independently associated with arterial stiffness and nondipping blood pressure in patients with hypertension regardless of sex.
- Published
- 2016