1. [Protective effect of rosiglitazone on myocardium in diabetic cardiomyopathy of rats].
- Author
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Lu YL, Wang YN, Zhang L, Zhu L, Zhao JB, Wu H, Wang NC, Wang XF, and Yu DL
- Subjects
- Animals, Cardiomyopathies drug therapy, Cardiomyopathies etiology, Cardiotonic Agents therapeutic use, Diabetes Mellitus, Experimental drug therapy, Hypoglycemic Agents therapeutic use, Ligands, Male, Rats, Rats, Sprague-Dawley, Rosiglitazone, Cardiomyopathies pathology, Diabetes Mellitus, Experimental complications, Myocardium ultrastructure, PPAR gamma therapeutic use, Thiazolidinediones therapeutic use
- Abstract
Objective: To investigate the protective effect of PPARgamma ligands rosiglitazone on myocardium in diabetic cardiomyopathy of rats., Methods: The rat model of diabetes was induced by administration of streptozotocin (STZ) for 6 or 10 weeks. In the treatment group the STZ-induced diabetic rats were treated with rosiglitazone. The left ventricular muscle specimens were taken from treatment and control group; then were examined under transmission electron microscope., Result: Cardiac myofibrils of diabetic rats in control group were obviously fewer and broken. There were fewer and smaller dissolved mitochondria with incomplete membrane and mixed cristae and karyopyknosis. Myocardium of diabetic rats treated with rosiglitazone was markedly improved although their blood glucose levels were still high., Conclusion: Hyperglycemia can cause destruction of myocardial cell structure. Rosiglitazone has protective effect on myocardial cells of diabetic rats, which seems to be independent of blood glucose levels.
- Published
- 2006
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