1. The role of Levosimendan in cardiopulmonary resuscitation.
- Author
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Varvarousi G, Stefaniotou A, Varvaroussis D, Aroni F, and Xanthos T
- Subjects
- Animals, Brain Injuries drug therapy, Brain Injuries physiopathology, Heart Arrest drug therapy, Heart Arrest physiopathology, Humans, Simendan, Cardiopulmonary Resuscitation, Cardiotonic Agents therapeutic use, Hydrazones therapeutic use, Pyridazines therapeutic use, Vasoconstrictor Agents therapeutic use
- Abstract
Although initial resuscitation from cardiac arrest (CA) has increased over the past years, long term survival rates remain dismal. Epinephrine is the vasopressor of choice in the treatment of CA. However, its efficacy has been questioned, as it has no apparent benefits for long-term survival or favorable neurologic outcome. Levosimendan is an inodilator with cardioprotective and neuroprotective effects. Several studies suggest that it is associated with increased rates of return of spontaneous circulation as well as improved post-resuscitation myocardial function and neurological outcome. The purpose of this article is to review the properties of Levosimendan during cardiopulmonary resuscitation (CPR) and also to summarize existing evidence regarding the use of Levosimendan in the treatment of CA., (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Published
- 2014
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