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Objectives: The impact of age on hospital survival for patients treated with extracorporeal cardiopulmonary resuscitation (ECPR) for cardiac arrest (CA) is unknown. We sought to characterize the association between older age and hospital survival after ECPR, using a large international database., Design: Retrospective analysis of the Extracorporeal Life Support Organization registry., Patients: Patients 18 years old or older who underwent ECPR for CA between December 1, 2016, and October 31, 2020., Measurements and Main Results: The primary outcome was adjusted odds ratio (aOR) of death after ECPR, analyzed by age group (18-49, 50-64, 65-74, and > 75 yr). A total of 5,120 patients met inclusion criteria. The median age was 57 years (interquartile range, 46-66 yr). There was a significantly lower aOR of survival for those 65-74 (0.68l 95% CI, 0.57-0.81) or those greater than 75 (0.54; 95% CI, 0.41-0.69), compared with 18-49. Patients 50-64 had a significantly higher aOR of survival compared with those 65-74 and greater than 75; however, there was no difference in survival between the two youngest groups (aOR, 0.91; 95% CI, 0.79-1.05). A sensitivity analysis using alternative age categories (18-64, 65-69, 70-74, and ≥ 75) demonstrated decreased odds of survival for age greater than or equal to 65 compared with patients younger than 65 (for age 65-69: odds ratio [OR], 0.71; 95% CI, 0.59-0.86; for age 70-74: OR, 0.84; 95% CI, 0.67-1.04; and for age ≥ 75: OR, 0.64; 95% CI, 0.50-0.81)., Conclusions: This investigation represents the largest analysis of the relationship of older age on ECPR outcomes. We found that the odds of hospital survival for patients with CA treated with ECPR diminishes with increasing age, with significantly decreased odds of survival after age 65, despite controlling for illness severity and comorbidities. However, findings from this observational data have significant limitations and further studies are needed to evaluate these findings prospectively., Competing Interests: Dr. George is funded in part by grant number CTSC008-12 from the Clinical & Translational Science Center at the University of New Mexico, under the National Center for Advancing Translational Sciences, National Institutes of Health grant number UL1TR001449. Dr. Ouchi is supported by National Institute on Aging (K76AG064434) and Cambia Health Foundation; he received funding from Jolly Good; he received support for article research from the National Institutes of Health. Dr. Myaskovsky’s work on this project is funded in part by grant number C-3924 from Dialysis Clinic, a national nonprofit dialysis provider. Dr. Kamdar received funding from the University of New Mexico, Stanford University, and Lucent Surgical. The remaining authors have disclosed that they do not have any potential conflicts of interest., (Copyright © 2023 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.)