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[Objectives] The study aimed to discuss the relationship of cardiovascular and cerebrovascular diseases to meteorological conditions and forecast method in Nanjing City. [Method] Based on daily cases of cardiovascular and cerebrovascular diseases from a hospital in Nanjing City as well as daily meteorological data from Nanjing Meteorological Station from January 2003 to July 2008, the monthly and seasonal variations in quantity of patients suffering from cardiovascular and cerebrovascular diseases in Nanjing City were analyzed firstly, and then the relationship between meteorological elements and incidence of the diseases was discussed, finally the forecast model for the incidence of the diseases was established using the stepwise regression method. [Result] Cardiovascular and cerebrovascular diseases in Nanjing City happened all the year round, and the incidence was high in the seasonal transition phase from autumn to winter. Daily incidence of the diseases in Nanjing City correlated negatively with daily maximum, minimum and average vapor pressure, daily minimum relative humidity and so forth, but their incidence had positive correlations with diurnal range of daily temperature, daily maximum, minimum and average pressure. Daily average number of patients suffering from the diseases obviously correlated with daily average temperature, daily maximum vapor pressure and daily average relative humidity. [Conclusion] The research could provide scientific references for the prevention and forecast of cardiovascular and cerebrovascular diseases in future. [ABSTRACT FROM AUTHOR]