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2 results on '"Folino, F"'

1. GLP-1RA and SGLT2i: Cardiovascular Impact on Diabetic Patients.

Author

Pablo A, Evelyn B, Claudia F, and Yanina MA

Subjects
Glucagon-Like Peptide-1 Receptor, Humans, Hypoglycemic Agents adverse effects, Cardiovascular Diseases diagnosis, Cardiovascular Diseases drug therapy, Cardiovascular Diseases prevention & control, Diabetes Mellitus, Type 2 diagnosis, Diabetes Mellitus, Type 2 drug therapy, Pharmaceutical Preparations, Sodium-Glucose Transporter 2 Inhibitors adverse effects
Abstract

Background: Diabetes is a chronic disease with high complexity that demands strategic medical care with a multifactorial risk-reduction approach. Over the past decade, the treatment of type 2 diabetes mellitus (T2DM) has entirely changed. One of the paradigm changes has been the arrival of new drugs that reduce cardiovascular risk beyond the reduction of A1C., Objective: Sodium-glucose cotransporter 2 (SGLT2i) and glucagon-like peptide-1 receptor agonist (GLP-1RA) are two groups of antidiabetics drugs, which have demonstrated superiority compared to placebo for major cardiovascular events (MACE)., Methods: We update and discuss their impact on MACE expressed as relative risk (HR hazard ratio) and as the number needed to treat (NNT) to avoid one cardiovascular event in 5 years. We include the publications of the last 10 years., Results: Empagliflozin, Canagliflozin and Dapagliflozin present an HR for MACE of 0.86, 0.86, 0.86 and an NNT of 38, 44, and 33, respectively (Dapagliflozin in secondary prevention). Regarding HHF (Hospitalization for Heart Failure), the HR was 0.65, 0.67, 0.73 and NNT was 44, 62, and 98, respectively. Lixisenatide, Exenatide, Liragutide, Semaglutide, Albiglutide and Dulaglutide presented for MACE an HR of 1.02, 0.91, 0.87, 0.74, 0.78, 0.88, respectively. There was no increase in the risk of HHF, but there was no benefit either., Conclusion: Cardiovascular benefits of the GLP-1RA and the SGLT2i are clinically significant. A number needed to treat under 50 is required to avoid one MACE in five years. These benefits have led to important changes in the Clinical Practice Guidelines and in the care of our patients with T2DM., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2021
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2. Reproducibility of electrocardiographic findings in patients with suspected reflex neurally-mediated syncope

Author

Brignole, M, Sutton, R, Menozzi, C, Moya, A, Garcia-Civera, R, G Benditt, D, Vardas, P, Wieling, W, Andresen, D, Migliorini, R, Hollinworth, D, Grovale, N, Zanna, F, P Lopez, M, Mohammad, S, Guthmann, A, Manders, M, D Van Aggel, Erckens, D, Andersen, V, Sousani, E, Eppacher, C, J St Ores, T De Santo, Bottoni, N, Ammirati, F, Santini, M, Donateo, P, Reviele, A, Giada, F, Orazi, S, Alboni, P, Dinelli, M, Perego, G, Brambilla, R, A Del Rosso, Vincenti, A, S De Ceglia, Sassone, B, T Baratto, M, Ungar, A, Currò, S, Gulizia, M, Francese, M, Pandolfo, L, Burattini, M, Cornacchia, D, Casali, E, Giani, P, Santangelo, L, Panico, S, G De Marchi, Marchetti, A, Buja, G, Folino, F, Spampinato, A, Bruni, G, Lunati, M, Buttera, G, García-Civera, R, Morell, S, Ruiz, R, Sanjuan, R, F Garcia-Sacristan, J, Beiras, X, Campos, G, Alonso, C, Garcia-Alberola, A, Lacuna, J, P Villacastín, J, Castellanos, P, Roda, J, Palanca, V, Martí, J, Delclós, J, Alvarez, M, Tercedor, L, Castellanos, E, Mauri, T, F Lozano, I, Tomás, J, Bènèzet, J, Fidalgo, M, G Martinez, J, Herreros, B, Muñoz, F, A J, J Aerts, L V, A Boersma, M Schroeder-Tanka, J, R Van Mechelen, H Ruiter, J, Ehlers, C, Meinerts, T, Schuchert, A, Vieth, T, Reithmann, C, P Von Lowis, Cripps, T, Sulke, N, A Kenny, R, D Skehan, J, Paul, V, Wrigley, M, E Louridas, G, Vasilikos, V, N Jakobsen, T, H Simonsen, E, B Johansen, J, W Grander Affiliation, ACS - Amsterdam Cardiovascular Sciences, and General Internal Medicine

Subjects
Male, medicine.medical_specialty, Socio-culturale, Neurological disorder, Ventricular tachycardia, Electrocardiography, Internal medicine, medicine, Syncope, Vasovagal, Humans, Sinus rhythm, Prospective Studies, cardiovascular diseases, Asystole, Prospective cohort study, medicine.diagnostic_test, biology, business.industry, Syncope (genus), Reproducibility of Results, Middle Aged, medicine.disease, biology.organism_classification, Electrocardiographic Finding, Anesthesia, Cardiology, cardiovascular system, Female, Cardiology and Cardiovascular Medicine, business
Abstract

The reproducibility of electrocardiographic (ECG) recordings in syncopal recurrences and the diagnostic role of nonsyncopal arrhythmias are not well known. The objective of this study was to analyse the reproducibility of the ECG findings recorded with implantable loop recorders in 41 patients with suspected neurally-mediated syncope who were included in the International Study on Syncope of Uncertain Origin-2 study and that had > or =2 events recorded by implantable loop recorders. In these patients, the electrocardiogram obtained with the first documented syncope (index syncope) was compared with other recorded events. Twenty-two patients had > or =2 syncopes, and their electrocardiograms were reproducible in 21 (95%): 15 with sinus rhythm, 5 with asystole, and 1 with ventricular tachycardia; 1 had asystole at first syncope and sinus rhythm at recurrent syncope. In 32 patients with nonsyncopal episodes, an arrhythmia was documented in 9, and all of them had the same arrhythmia during the index syncope (100% reproducibility); conversely, when sinus rhythm was documented (23 patients) during nonsyncopal episodes, an arrhythmia was still documented in 6 during the index syncope (70% reproducibility; p = 0.0004). In conclusion, the ECG findings during the first syncope are highly reproducible in subsequent syncopes. The presence of an arrhythmia during nonsyncopal episodes is also highly predictive of the mechanism of syncope, but the presence of sinus rhythm does not rule out the possibility of arrhythmia during syncope. Therefore the finding of an arrhythmia during a nonsyncopal episode allows the etiologic diagnosis of syncope, and eventually to anticipate treatment, without waiting for syncope

Published
2008

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