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Researchers at Zhejiang Chinese Medical University have developed biomimetic nanoparticles that co-deliver hirudin and lumbrukinase to target thrombus and inflammation in atherosclerosis therapy. The nanoparticles, known as HMTL@PM, showed promising results in alleviating inflammation, dissolving thrombus, anticoagulation, and promoting cholesterol efflux. This innovative approach may offer new perspectives on drug delivery systems for atherosclerosis therapy, potentially reducing mortality from cardiovascular and cerebrovascular diseases. The study was funded by Zhejiang Province Natural Science Foundation and the National Natural Science Foundation of China. [Extracted from the article]

Researchers from the University of California Los Angeles School of Dentistry have found that the peptide GV1001 can prevent doxorubicin-induced atherosclerosis by protecting vascular endothelial cells from mitochondrial dysfunction, inflammation, and phenotypic changes. This peptide has shown inhibitory effects on endothelial-to-mesenchymal transition (EndMT) induced by doxorubicin, potentially reducing the long-term cardiovascular side effects associated with this anticancer treatment. The study suggests that GV1001 could be a promising therapeutic agent for mitigating atherosclerosis in humans. [Extracted from the article]

A recent study from Yale University School of Medicine explores the impact of cancer therapies on cardiovascular health, specifically focusing on cardiomyopathies. The research emphasizes the importance of multimodal cardiac imaging in diagnosing pathologies such as left ventricular dysfunction, myocarditis, and accelerated atherosclerosis in cancer patients. As the field of cardio-oncology expands, the development of imaging technologies and guidance on managing toxicities become crucial for patient care. The study presents complex cases of atherosclerosis and myocarditis in cancer patients, highlighting the role of various cardiac imaging modalities in diagnosis and management. [Extracted from the article]

A recent study conducted at the University of California Davis examined the association between menopausal age and various anthropometric measures and sex hormones among postmenopausal women. The study included 2,436 women from the Multi-Ethnic Study of Atherosclerosis and found that women with late menopause had higher waist circumference, waist-hip ratio, and waist-height ratio compared to those in the referent category. Additionally, women with late menopause had higher levels of the total testosterone-estradiol ratio, while women who experienced menopause between 45 and 49 years had higher levels of dehydroepiandrosterone. The research concluded that androgenicity was higher among women with late menopause and those who experienced menopause between 45 and 49 years. [Extracted from the article]

A recent study on atherosclerosis highlights the potential role of stem cell-derived exosomes in managing the disease. Exosomes play a crucial role in controlling inflammation, angiogenesis, and senescence, key factors in atherosclerosis development. The research explores how engineering exosomes can enhance their therapeutic capabilities, offering a promising avenue for treating cardiovascular diseases. The study provides insights into the mechanisms of action and challenges in utilizing exosome delivery systems for atherosclerosis treatment. [Extracted from the article]

A research team led by Prof. WENG Jianping from the University of Science and Technology of China identified insulin-like growth factor-binding protein 6 (IGFBP6) as a potential therapeutic target for suppressing endothelial inflammation and atherosclerosis. Their work, published in Nature Cardiovascular Research, highlights the role of IGFBP6 in regulating cell cycle, proliferation, and migration, with implications for treating atherosclerotic cardiovascular disease. By targeting IGFBP6, researchers aim to address the inflammatory risk associated with atherosclerosis, offering new hope for cardiovascular disease treatment. [Extracted from the article]

A patent application titled "Methods For Treating Lysosomal Acid Lipase Deficiency In Patients" was published online, focusing on a rare lysosomal storage disease characterized by the accumulation of lipids in various tissues. The disease presents in two forms: Wolman Disease and Cholesteryl Ester Storage Disease, with severe symptoms and high mortality rates. The application discusses the use of exogenous lysosomal acid lipase (LAL) as a potential treatment, showing promising results in clinical cases. This innovative therapy aims to improve the quality of life for patients suffering from LAL deficiency. [Extracted from the article]

A recent study conducted by researchers at the Icahn School of Medicine at Mount Sinai explored the relationship between subclinical vascular disorders and cognitive decline. The study, which included a diverse cohort of 6,814 participants, found that arteriosclerosis and atherosclerosis were independently associated with greater cognitive decline, lower domain-specific cognitive performance, and higher odds of cognitive impairment over a 20-year period. These findings suggest that arteriosclerosis and atherosclerosis may have a more consistent impact on cognitive impairment and decline compared to cardiac function and blood pressure in a diverse population. [Extracted from the article]

Researchers at NHS Grampian in Aberdeen, United Kingdom conducted a feasibility study to monitor intramuscular pH (IMpH) before and during exercise in individuals with intermittent claudication (IC) compared to healthy controls. The study found that IMpH monitoring with a glass probe inserted into the tibialis anterior muscle is viable, and changes in IMpH during static and dynamic exercises can be detected. This research was supported by Scottish Enterprise and has been peer-reviewed, providing valuable insights into cardiovascular health and exercise physiology. [Extracted from the article]

A recent study conducted by researchers at the University of Pennsylvania focused on the relationship between subclinical cardiovascular assessments in midlife and neuroimaging biomarkers related to dementia 17-20 years later. The study, part of the Multi-Ethnic Study of Atherosclerosis (MESA), identified specific subclinical composites of arteriosclerosis, atherosclerosis, cardiac function, and blood pressure that were associated with cognitive impairment and dementia. The findings suggest that these subclinical vascular risk factors may offer insights into potential pathways to dementia, with implications for developing trajectory-based prediction models for assessing vascular aging. [Extracted from the article]

University of California researchers conducted a study on South Asian adults living in America to explore the relationship between adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and coronary artery calcification, an early predictor of atherosclerotic cardiovascular disease. The study found that participants with high adherence to the DASH diet were less likely to have high coronary artery calcification scores, particularly men. This research suggests that the DASH diet may be a modifiable risk factor that could help mitigate the progression of atherosclerosis in high-risk populations. [Extracted from the article]

Researchers have submitted a patent application for "Systems And Methods For Processing Images To Analyze Perfusion" to the USPTO. The application aims to estimate perfusion of target tissue using patient-specific physiological parameters to guide diagnosis and treatment of cardiovascular disease. The method involves receiving patient-specific vessel and tissue models, extracting physiological parameters, estimating perfusion characteristics, and displaying the results on a screen. This innovative approach could potentially improve the assessment and treatment of cardiovascular diseases. [Extracted from the article]

University of Leicester researchers have updated their findings on heart disease, specifically focusing on osteopontin (OPN) as a potential biomarker for coronary artery disease (CAD). The study suggests that plasma levels of OPN may correlate with the presence of CAD, offering potential as a biomarker for early diagnosis, disease monitoring, and prognosis. While OPN has been linked to higher cardiovascular risk and unfavorable outcomes, its role as a marker of poor prognosis rather than a direct indicator of CAD severity is emphasized. [Extracted from the article]

Researchers from the Cardiology Department in Izmir, Turkey, conducted a study to evaluate the diagnostic potential of CTRP5 and chemerin in distinguishing between coronary artery disease (CAD) and non-CAD using coronary computed tomography angiography (CCTA). They found that CTRP5 and chemerin levels were significantly higher in the CAD group compared to the non-CAD group, with CTRP5 showing greater sensitivity and specificity. However, neither adipokine was correlated with CAD severity and extent, contrasting with findings from invasive coronary angiography (ICA). This study suggests that CTRP5 may be a promising biomarker for the presence of CAD. [Extracted from the article]

Researchers from the Lithuanian University of Health Sciences have published a study on the impact of obsessive-compulsive personality disorder (OCPD) on cognitive flexibility in individuals with coronary artery disease (CAD). The study found that individuals with comorbid OCPD traits exhibited greater cognitive inflexibility and slower planning compared to those without OCPD. These findings suggest that OCPD traits may affect the success of rehabilitation for individuals with CAD. The study was supported by the Research Council of Lithuania and published in Comprehensive Psychiatry. [Extracted from the article]

A study conducted in Hsinchu, Taiwan, analyzed the association between body mass index (BMI) and cardiovascular events in patients with coronary artery disease undergoing percutaneous coronary intervention (PCI). The research found a J-shaped relationship between BMI and future adverse events, with individuals having a BMI of 25.0-29.9 kg/m2 showing lower risks of cardiovascular events compared to those with a BMI of 22.0-24.9 kg/m2. This study suggests that overweight individuals may have a lower risk of total cardiovascular events post-PCI. [Extracted from the article]

A recent study from the University of California highlights a challenging case where a patient with severe portal vein thrombosis and coronary artery disease experienced a significant bleed post TIPS procedure, leading to emergent ligation of portal structures and urgent liver transplantation. The patient later underwent successful coronary artery bypass grafting after the liver transplantation. This case showcases an unconventional approach to managing portal vein hemorrhage and performing coronary artery bypass grafting post-liver transplantation. The research provides valuable insights into emergent management strategies for patients with complex medical conditions. [Extracted from the article]

Researchers from Transilvania University conducted a study on patients with severe coronary artery disease to evaluate the role of endothelial dysfunction and oxidative stress, particularly in relation to type 2 diabetes mellitus (T2DM). The study found that patients with T2DM had more severe endothelial dysfunction and higher levels of plasma serotonin compared to those without T2DM. However, oxidative stress markers did not show significant differences between the two groups. The researchers suggest that targeting serotonin receptors may be beneficial for patients with T2DM undergoing coronary artery bypass graft surgery. [Extracted from the article]

Researchers from the Affiliated Hospital of Southwest Medical University conducted a cohort study to evaluate the prognosis of patients with hypertrophic cardiomyopathy (HCM) and coronary artery disease (CAD). The study included 2167 patients over a 6.4-year follow-up period, with 20.6% mortality rate. The research found that the presence of CAD did not significantly impact the incidence of sudden cardiac death, cardiovascular death, or all-cause mortality in patients with HCM. This study highlights the complexity of mortality risk factors in HCM patients. [Extracted from the article]

Researchers at Chengdu First People's Hospital conducted a study on the hemoglobin-to-red blood cell distribution width ratio (HRR) as a potential protective factor against coronary artery disease (CAD). The study, based on data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018, found that higher HRR levels were associated with a lower risk of CAD. The research suggests that individuals with an HRR above 1.02 may benefit from strategies to increase body water content and reduce blood viscosity to lower their risk of developing CAD. [Extracted from the article]

A recent study from the University of Houston examined the effects of exercise training on vascular endothelial function and blood lipid variables in patients with coronary artery disease (CAD). The study found that exercise training significantly increased brachial artery flow-mediated dilation (FMD) and high-density lipoprotein-cholesterol (HDL-C) levels, but had no effect on low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG). The researchers concluded that exercise-induced improvement in vascular endothelial function is associated with increased HDL-C levels in patients with CAD. [Extracted from the article]

Researchers at Kurdistan University conducted a study on heart disease, specifically focusing on non-imaging findings in myocardial perfusion imaging (MPI) in patients with suspected coronary artery disease (CAD). The study examined the relationship between heart rate, pulmonary uptake, and clinical risk factors in 354 non-smokers with suspected CAD. The research found that diabetes and hypertension increased resting heart rate (RHR), while age and gender were the main factors affecting peak heart rate after dipyridamole injection (PHR). Additionally, male gender was associated with abnormal lung-to-heart ratio (LHR) in the stress phase of MPI. [Extracted from the article]

Researchers at the University of Copenhagen conducted a study comparing the prevalence of subclinical coronary atherosclerosis in persons with HIV (PWH) and the general population. The study found that PWH had a higher prevalence of both any and obstructive coronary atherosclerosis compared to population controls, even after adjusting for cardiovascular risk factors. The research suggests that HIV is independently associated with a three-fold higher risk of subclinical obstructive coronary atherosclerosis, potentially explaining the elevated risk of myocardial infarction observed in PWH. The study was supported by various organizations and has been peer-reviewed. [Extracted from the article]

A recent study conducted at Hospital Universitario Ramon y Cajal in Madrid, Spain, focused on understanding the role of glycoprotein and lipoprotein lipidomics in predicting carotid subclinical atherosclerosis in patients with type 1 diabetes (T1D). The study included 256 T1D patients and found that traditional clinical risk factors such as age, duration of diabetes, and smoking status were strong determinants of subclinical atherosclerosis. While glycoprotein and lipoprotein lipidomics profiles were associated with atherosclerosis, they did not significantly improve the diagnostic accuracy of predictive models beyond clinical variables. The study concluded that the predictive model remained effective even in the presence of cardiac autonomic neuropathy (CAN), highlighting its reliability as a screening tool for identifying patients at risk of subclinical atherosclerosis. [Extracted from the article]

A recent study conducted by researchers at the School of Public Health focused on the cost-effectiveness of statin therapy initiation thresholds for atherosclerosis prevention in China. The study evaluated different strategies and found that maintaining the recommended thresholds outlined in the current guidelines for dyslipidemia management may be a cost-effective option for China. The research highlighted the impact of variations in statin prices and the risk of statin-induced diabetes on cost-effectiveness outcomes. For more information, readers can access the full article in the International Journal for Equity in Health. [Extracted from the article]

The article discusses how endothelial cells sense disturbed blood flow, leading to mitochondrial dysfunction and atherosclerosis. It highlights the role of copper in atherosclerosis and the importance of Cu transport proteins like CTR1 in regulating cellular Cu levels. The study suggests that targeting the endothelial CTR1-SLC25A3-mitochondrial Cu axis could be a potential therapeutic approach for atherosclerosis. The research is available as a preprint and has not been peer-reviewed. [Extracted from the article]

The article discusses a study that utilized single-cell multimodal profiling to identify a novel CD26+ fibroblast subpopulation in atherosclerosis. The research aimed to understand the diverse functions of fibroblasts and distinguish between subsets that may have protective or pathogenic roles in the disease process. The study found that CD26+ fibroblasts expand within atherosclerotic lesions and may play a critical role in promoting plaque stability by migrating into the fibrous cap. This preprint has not been peer-reviewed and provides valuable insights into the phenotypic diversity and dynamic changes of fibroblasts during atherosclerosis progression. [Extracted from the article]

The article discusses the development of a new therapy using OxLDL-targeted Chimeric Antigen Receptor T Regulatory Cells to reduce atherosclerotic plaque formation. Atherosclerosis, caused by the accumulation of LDL and OxLDL, is a major contributor to cardiovascular disease. The study shows promising results in reducing plaque formation in mouse models, offering a potential new therapeutic option for atherosclerosis. The research is available as a preprint and has not yet undergone peer review. [Extracted from the article]

A study conducted in Jinan, People's Republic of China, explored the role of endothelial Gs alpha in atherosclerosis and ferroptosis in mice lacking apolipoprotein E. The research found that Gs alpha deficiency exacerbated atherosclerotic lesions and ferroptosis, while Gs alpha overexpression reduced oxidative stress and lipid peroxidation. The study suggests that Gs alpha could be a potential target for treating atherosclerosis and related heart diseases. The findings were published in Acta Pharmacologica Sinica and have been peer-reviewed. [Extracted from the article]

A recent research report from Shaanxi Provincial People's Hospital delves into the relationship between Ne-carboxyethyl-lysin (CEL) and atherosclerotic plaque stability in patients with coronary artery disease, particularly those with Type 2 diabetes mellitus (T2DM). The study found that elevated serum CEL levels were associated with increased incidence of acute coronary syndrome (ACS) and contributed to plaque instability in diabetic conditions by disrupting macrophage autophagy. The research highlights potential therapeutic targets for managing atherosclerosis in diabetic patients by targeting key molecular pathways that regulate autophagy. [Extracted from the article]

Researchers from Medical University Lublin in Poland conducted a study on using Raman spectroscopy combined with machine learning and chemometrics analyses to identify atherosclerotic carotid stenosis (ACS) from serum samples. The study aimed to detect ACS, a leading cause of stroke, during routine tests as the disease often presents without obvious symptoms. Results showed promising potential for Raman spectroscopy in accurately detecting ACS from serum samples, with machine learning algorithms demonstrating high accuracy, sensitivity, and selectivity. The research findings were published in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy and have been peer-reviewed. [Extracted from the article]

Researchers at the First Affiliated Hospital of Bengbu Medical University in China conducted a study on the use of percutaneous transluminal angioplasty with stenting (PTAS) for treating lower limb arteriosclerosis obliterans (ASO). The study included 96 ASO patients and found that PTAS was more effective than traditional percutaneous transluminal angioplasty (PTA) in improving clinical outcomes. Patients who underwent PTAS showed higher rates of improvement in functional indicators and a lower rate of target lesion revascularization (TLR) compared to those who received PTA. The study suggests that PTAS may be a beneficial treatment option for patients with lower limb ASO. [Extracted from the article]

A recent study conducted by researchers from the University of California focused on the impact of neighborhood social cohesion on dementia risk among South Asian populations in the US. The study analyzed data from 745 South Asian individuals and found that greater neighborhood social cohesion was associated with lower dementia risk scores, particularly among women. The findings suggest that neighborhood social cohesion may play a role in reducing the risk of dementia in South Asian middle to older-age women in the US. [Extracted from the article]

The article from Cardiovascular Week discusses a study on atherosclerosis conducted by researchers at Poznan University of Medical Sciences in Poland. The study highlights that atherosclerosis is now classified as a chronic inflammatory disease rather than just a lipid storage disease. It emphasizes the role of various clinical factors such as hypertension, hyperlipidemia, and inflammatory status in the development of atherosclerosis, as well as the involvement of different cells in the process. The research aims to summarize the phases of atherosclerotic formation and the cells that either promote or inhibit its development. [Extracted from the article]

A recent study conducted at Hainan Medical University in Haikou, People's Republic of China, focused on developing a nanomedicine delivery system for the treatment of atherosclerosis. The system combines targeted photothermal therapy with drug treatment to slow the progression of the disease through lipid-lowering and anti-inflammatory effects. Both in vitro and in vivo experiments demonstrated the material's biocompatibility and its ability to inhibit the developmental process of atherosclerosis, offering new insights into safe and effective treatments for the condition. [Extracted from the article]

A study conducted by Yale University School of Medicine found that lower slow wave sleep and rapid eye movement sleep are associated with brain atrophy in regions vulnerable to Alzheimer's disease. The research, which examined the sleep architecture of participants over a 17-year period, concluded that sleep deficiency may be a modifiable risk factor for Alzheimer's disease pathogenesis. The study focused on the association between sleep patterns and anatomical features frequently observed in Alzheimer's disease, such as atrophy of specific brain regions. [Extracted from the article]

A recent study from the Medical University of Silesia in Katowice, Poland, explores the potential of osteoprotegerin (OPG) as a biomarker for carotid artery stenosis (CAS) and atherosclerosis. The research suggests that increased levels of serum OPG may be linked to unstable atherosclerotic plaques, regardless of the location of atherosclerosis. However, the study also notes that chronic kidney disease can impact the usefulness of OPG as a biomarker in CAS. For more information, readers can refer to the article "Osteoprotegerin as an Emerging Biomarker of Carotid Artery Stenosis? A Scoping Review with Meta-Analysis" published in Diagnostics. [Extracted from the article]

A recent study from Chiang Mai University explores the inhibitory effects of panduratin A on TNF Alpha-stimulated endothelial cell activation through suppressing the NF-kB pathway. The research suggests that panduratin A may be effective in blocking the pathophysiology of atherosclerosis by reducing pro-inflammatory cytokines, chemokines, and adhesion molecules. This study provides valuable insights into potential preventive measures for cardiovascular diseases. For more information, readers can access the full article in Biomolecules. [Extracted from the article]

A study conducted at Kumamoto University Hospital in Japan explored the use of an artificial dural regeneration matrix called DuraGen as a substitute for autologous tissue in indirect bypass surgery for Moyamoya disease. The research, supported by Grants-in-Aid for Scientific Research, involved a rat model of chronic cerebral hypoperfusion and found that DuraGen resulted in increased angiogenesis comparable to using autologous tissue. The study concluded that DuraGen may be a viable option for indirect bypass procedures in patients with Moyamoya disease. [Extracted from the article]

Researchers from King's College London conducted a study on atherosclerosis, a common cause of cardiovascular disease. The study focused on the impact of modifiable risk factors, such as diabetes, smoking, and hypertension, on the DNA methylation patterns in endothelial cells. The research suggests that changes in DNA methylation within endothelial cells may contribute to endothelial cell dysfunction, leading to atherosclerosis and cardiovascular disease. The study highlights the potential role of environmental risk factors in altering gene transcription and function through epigenetic mechanisms. [Extracted from the article]

A recent study conducted by researchers at the University of California introduced the ARTS biomarker, a software container that predicts arteriolosclerosis based on MRI data and demographic features. The study involved instrumental and clinical validation of ARTS, demonstrating excellent reliability and reproducibility. The findings suggest that baseline ARTS scores are associated with cognitive decline, indicating its potential as a marker for vascular contributions to cognitive impairment and dementia. The research was published in Alzheimer's & Dementia and can be accessed for free online. [Extracted from the article]

A recent study from the University of Texas Health Science Center Houston explores the role of personalized medicine in treating atherosclerosis, a major driver of cardiovascular disease. The research highlights the importance of the gut microbiome in atherosclerosis progression and suggests personalized treatment strategies using Artificial Intelligence (AI) to analyze individual gut microbiome profiles. By tailoring interventions based on unique microbiota signatures, the study aims to improve outcomes for atherosclerosis patients. [Extracted from the article]

A study conducted in Madhya Pradesh, India, explored the inter-relationship between thyroid and lipid profiles in obese individuals. The research found that hypothyroidism is associated with increased total cholesterol, triglycerides, LDL cholesterol, and decreased HDL cholesterol in obese individuals. The study suggests that clinicians should be vigilant of lipid abnormalities in middle-aged females with hypothyroidism to prevent the risk of atherosclerosis and coronary artery disease. The study was conducted at a tertiary care center in central India and included 101 individuals diagnosed with obesity. [Extracted from the article]

A recent study from Shandong University of Traditional Chinese Medicine explored the shared diagnostic genes and molecular mechanisms between obesity and atherosclerosis using bioinformatic analysis. The research identified SAMSN1 and PHGDH as potential diagnostic genes for both conditions, shedding light on the molecular connections between obesity and atherosclerosis. The study utilized various analytical tools and datasets to uncover 56 shared genes with the same expression trend, emphasizing the importance of understanding the genetic underpinnings of the obesity-atherosclerosis link. [Extracted from the article]

A recent report from the Medical University of Warsaw discusses the challenges of diagnosing and treating arterial hypertension in pediatric patients. The case study focuses on a 15-year-old girl with severe symptomatic hypertension, successfully managed through percutaneous transluminal renal angioplasties. The research emphasizes the importance of considering secondary hypertension in children with elevated blood pressure and highlights the need for a multidisciplinary approach to diagnosis and treatment. This study underscores the significance of specialized care in managing similar cases for optimal patient outcomes. [Extracted from the article]

A study conducted in Shandong, People's Republic of China, focused on the therapeutic effects of Huanglian Wendan (HLWD) decoction, a traditional Chinese medicine, on metabolic-associated fatty liver disease (MAFLD) associated with atherosclerosis. The research aimed to identify the active compounds in HLWD and elucidate the mechanisms by which it affects MAFLD and atherosclerosis. Through systematic pharmacology methods and experimental validation, the study found that HLWD improved liver appearance, reduced body weight, blood lipids, and inflammation, indicating potential benefits in treating MAFLD associated with atherosclerosis. The research concluded that combining pharmacochemistry research, network pharmacology analysis, and experimental verification can provide a comprehensive model for studying traditional Chinese medicine. [Extracted from the article]

A recent study conducted at the University of Calgary focused on the management approaches to intraluminal thrombi in acutely symptomatic carotid stenosis. The research aimed to map variations in medical management and timing of revascularization, as well as gather opinions to inform future trials in this area. The study found a preference for anticoagulation and delayed revascularization after reimaging, highlighting the need for further research to understand the natural history of this condition for future trial design. The research was supported by the Heart & Stroke Foundation of Canada and has been peer-reviewed. [Extracted from the article]

A recent study from Texas A&M University focused on evaluating sex-based differences in below-the-knee plaque histology in patients who underwent amputation for chronic limb-threatening ischemia. The research found that while male and female patients showed similarities in various plaque characteristics, there was a significant difference in the presence of luminal thrombus, which was more prevalent in females. The study concluded that these differences could impact treatment options and may guide decisions regarding antiplatelet and anticoagulation regimens. Further research is needed to assess the effects of these variations on outcomes of endovascular procedures. [Extracted from the article]

A recent study conducted at the University of Wisconsin found that patients with lupus nephritis (LN) are at a significantly higher risk of developing atherosclerotic cardiovascular disease (ASCVD), especially those under the age of 50. The research suggests that renal arteriosclerosis in kidney biopsies may be able to predict future ASCVD events in LN patients, highlighting the importance of identifying specific risk factors. Factors such as renal arteriosclerosis, area deprivation, and angiotensin converting enzyme inhibitor (ACEi) exposure were found to be associated with ASCVD occurrence, providing valuable insights for risk stratification in LN patients. Further prospective studies are needed to validate these findings and inform clinical practice. [Extracted from the article]

University of Gothenburg researchers conducted a study on 1,945 individuals to investigate the relationship between epicardial adipose tissue (EAT) and coronary artery calcifications (CAC) using computed tomography. The study found no significant association between EAT volume or attenuation and the presence or severity of CAC, even after adjusting for cardiovascular risk factors. The researchers concluded that while EAT may not be directly linked to CAC, it does not rule out potential early or local effects on coronary atherosclerosis. The study was funded by various organizations and published in the International Journal of Cardiology: Heart & Vasculature. [Extracted from the article]