1. High Density Lipoproteins: Metabolism, Function, and Therapeutic Potential
- Author
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Jomard, Anne, Osto, Elena, University of Zurich, and Osto, Elena
- Subjects
cardiovascular risk ,lipoproteins ,obesity ,endothelial function ,high density lipoprotein ,bariatric surgery ,540 Chemistry ,610 Medicine & health ,HDL-therapy ,Cardiology and Cardiovascular Medicine ,2705 Cardiology and Cardiovascular Medicine ,10038 Institute of Clinical Chemistry - Abstract
High Density Lipoproteins (HDLs) have long been considered as “good cholesterol,” beneficial to the whole body and, in particular, to cardio-vascular health. However, HDLs are complex particles that undergoes dynamic remodeling through interactions with various enzymes and tissues throughout their life cycle, making the complete understanding of its functions and roles more complicated than initially expected. In this review, we explore the novel understanding of HDLs' behavior in health and disease as a multifaceted class of lipoprotein, with different size subclasses, molecular composition, receptor interactions, and functionality. Further, we report on emergent HDL-based therapeutics tested in small and larger scale clinical trials and their mixed successes., Frontiers in Cardiovascular Medicine, 7, ISSN:2297-055X
- Published
- 2020