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Your search keyword '"MACE – Major Adverse Cardiovascular Events"' showing total 2 results
Start Over Descriptor "MACE – Major Adverse Cardiovascular Events" Topic cardiovascular system & hematology
2 results on '"MACE – Major Adverse Cardiovascular Events"'

1. Combined atrial fibrillation ablation and left atrial appendage occlusion procedure in the United States: a propensity score matched analysis from 2016–2019 national readmission database

Author

Pasupula, Deepak Kumar, Malleshappa, Sudeep K Siddappa, Munir, Muhammad B, Bhat, Anusha Ganapati, Anandaraj, Antony, Jakkoju, Avaneesh, Spooner, Michael, Koranne, Ketan, Hsu, Jonathan C, Olshansky, Brian, and Camm, A John

Subjects
Patient Safety, Heart Disease, Cardiovascular, Clinical Research, Male, Humans, United States, Middle Aged, Aged, Aged, 80 and over, Female, Atrial Fibrillation, Patient Readmission, Atrial Appendage, Propensity Score, Retrospective Studies, Stroke, Catheter Ablation, Treatment Outcome, LAAO, Left Atrial Appendage Occlusion, CA, Percutaneous Catheter-directed Atrial Fibrillation Ablation, MACE, Major Adverse Cardiovascular Events, NRD, National Readmission Database, CA – Percutaneous Catheter-directed Atrial Fibrillation Ablation, LAAO – Left Atrial Appendage Occlusion, MACE – Major Adverse Cardiovascular Events, NRD – National Readmission Database, Clinical Sciences, Cardiovascular System & Hematology
Abstract

AimsThe safety and feasibility of combining percutaneous catheter ablation (CA) for atrial fibrillation with left atrial appendage occlusion (LAAO) as a single procedure in the USA have not been investigated. We analyzed the US National Readmission Database (NRD) to investigate the incidence of combined LAAO + CA and compare major adverse cardiovascular events (MACEs) with matched LAAO-only and CA-only patients.Methods and resultsIn this retrospective study from NRD data, we identified patients undergoing combined LAAO and CA procedures on the same day in the USA from 2016 to 2019. A 1:1 propensity score match was performed to identify patients undergoing LAAO-only and CA-only procedures. The number of LAAO + CA procedures increased from 28 (2016) to 119 (2019). LAAO + CA patients (n = 375, mean age 74 ± 9.2 years, 53.4% were males) had non-significant higher MACE (8.1%) when compared with LAAO-only (n = 407, 5.3%) or CA-only patients (n = 406, 7.4%), which was primarily driven by higher rate of pericardial effusion (4.3%). All-cause 30-day readmission rates among LAAO + CA patients (10.7%) were similar when compared with LAAO-only (12.7%) or CA-only (17.5%) patients. The most frequent primary reason for readmissions among LAAO + CA and LAAO-only cohorts was heart failure (24.6 and 31.5%, respectively), while among the CA-only cohort, it was paroxysmal atrial fibrillation (25.7%).ConclusionWe report an 63% annual growth (from 28 procedures) in combined LAAO and CA procedures in the USA. There were no significant difference in MACE and all-cause 30-day readmission rates among LAAO + CA patients compared with matched LAAO-only or CA-only patients.

Published
2023

2. Combined atrial fibrillation ablation and left atrial appendage occlusion procedure in the United States: a propensity score matched analysis from 2016-2019 national readmission database

Author

Deepak Kumar Pasupula, Sudeep K Siddappa Malleshappa, Muhammad B Munir, Anusha Ganapati Bhat, Antony Anandaraj, Avaneesh Jakkoju, Michael Spooner, Ketan Koranne, Jonathan C Hsu, Brian Olshansky, and A John Camm

Subjects
Male, CA – Percutaneous Catheter-directed Atrial Fibrillation Ablation, Clinical Sciences, MACE, Cardiovascular, Patient Readmission, MACE – Major Adverse Cardiovascular Events, Clinical Research, Physiology (medical), Atrial Fibrillation, 80 and over, Humans, Atrial Appendage, LAAO, Propensity Score, Retrospective Studies, Aged, Left Atrial Appendage Occlusion, CA, Major Adverse Cardiovascular Events, National Readmission Database, Middle Aged, LAAO – Left Atrial Appendage Occlusion, United States, NRD – National Readmission Database, Stroke, Treatment Outcome, Heart Disease, NRD, Cardiovascular System & Hematology, Catheter Ablation, Female, Patient Safety, Cardiology and Cardiovascular Medicine, Percutaneous Catheter-directed Atrial Fibrillation Ablation
Abstract

AimsThe safety and feasibility of combining percutaneous catheter ablation (CA) for atrial fibrillation with left atrial appendage occlusion (LAAO) as a single procedure in the USA have not been investigated. We analyzed the US National Readmission Database (NRD) to investigate the incidence of combined LAAO + CA and compare major adverse cardiovascular events (MACEs) with matched LAAO-only and CA-only patients.Methods and resultsIn this retrospective study from NRD data, we identified patients undergoing combined LAAO and CA procedures on the same day in the USA from 2016 to 2019. A 1:1 propensity score match was performed to identify patients undergoing LAAO-only and CA-only procedures. The number of LAAO + CA procedures increased from 28 (2016) to 119 (2019). LAAO + CA patients (n = 375, mean age 74 ± 9.2 years, 53.4% were males) had non-significant higher MACE (8.1%) when compared with LAAO-only (n = 407, 5.3%) or CA-only patients (n = 406, 7.4%), which was primarily driven by higher rate of pericardial effusion (4.3%). All-cause 30-day readmission rates among LAAO + CA patients (10.7%) were similar when compared with LAAO-only (12.7%) or CA-only (17.5%) patients. The most frequent primary reason for readmissions among LAAO + CA and LAAO-only cohorts was heart failure (24.6 and 31.5%, respectively), while among the CA-only cohort, it was paroxysmal atrial fibrillation (25.7%).ConclusionWe report an 63% annual growth (from 28 procedures) in combined LAAO and CA procedures in the USA. There were no significant difference in MACE and all-cause 30-day readmission rates among LAAO + CA patients compared with matched LAAO-only or CA-only patients.

Published
2022

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