1. [3H]Imipramine binding and [3H]5HT uptake in human blood platelets: changes after one week chlorimipramine treatment.
- Author
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Poirier MF, Loo H, Benkelfat C, Sechter D, Zarifian E, Galzin AM, Schoemaker H, Segonzac A, and Langer SZ
- Subjects
- Adult, Female, Humans, In Vitro Techniques, Kinetics, Male, Middle Aged, Receptors, Neurotransmitter analysis, Tritium, Blood Platelets metabolism, Carrier Proteins, Clomipramine pharmacology, Imipramine blood, Receptors, Drug, Serotonin blood
- Abstract
In platelets of normal volunteers taking chlorimipramine (50 mg/day) for one week, the saturable uptake of [3H]5HT was fully inhibited at day 8, but returned to control values at day 15. The Bmax of [3H]imipramine binding was decreased by 65% at day 8 and remained significantly below control values at day 15. If the present findings can be extrapolated to other antidepressants, the reported decreases in [3H]imipramine binding in depression may partly reflect residual treatment effects. It cannot be excluded that, in depression, the platelet [3H]imipramine receptor already is down-regulated maximally which would preclude a further down-regulation due to antidepressant drug therapy.
- Published
- 1984
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