1. High Expression of Both Resistin and Fascin-1 Predicts a Poor Prognosis in Patients with Colorectal Cancer.
- Author
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Wang CQ, Wang Y, Huang BF, Tang CH, Du Z, Zeng Y, Wang Q, Shao JK, and Jin LL
- Subjects
- Adult, Aged, Disease-Free Survival, Female, Follow-Up Studies, Humans, Male, Middle Aged, Survival Rate, Carrier Proteins biosynthesis, Carrier Proteins genetics, Colorectal Neoplasms genetics, Colorectal Neoplasms metabolism, Colorectal Neoplasms mortality, Colorectal Neoplasms pathology, Gene Expression Regulation, Neoplastic, Microfilament Proteins biosynthesis, Microfilament Proteins genetics, Neoplasm Proteins biosynthesis, Neoplasm Proteins genetics, Resistin biosynthesis, Resistin genetics
- Abstract
Emerging evidence indicates that resistin and fascin-1 may possess a causal role in the development of several types of cancers. However, the clinical significance of resistin expression in colorectal cancer (CRC) tissues is unclear, and there are no reports of any correlation between resistin and fascin-1. Our analyses explored the expression of resistin in CRC tissue and analyzed the clinical and prognostic significance of the observed positive correlation between resistin and fascin-1. The rate of strongly positive resistin expression (27.5%) was significantly higher in CRC tissues than in normal colorectal tissues (5.2%). Strongly positive resistin expression is related to multiple poor prognostic factors in CRC, including depth of tumor invasion, lymph node metastasis, and tumor stage. In this study, survival was worse in CRC patients with high levels of both resistin and fascin-1 expression than in those with high levels of only one protein or normal levels of both proteins. We suggest that a combined high level of resistin and fascin-1 expression correlates reliably with survival in CRC, so it may serve as a potential therapeutic target., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2020 Chao-Qun Wang et al.)
- Published
- 2020
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