1. Association between human polyomavirus infection and brain cancer: A systematic review and meta-analysis
- Author
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Fariba Goudarzi far, Vahid Tambrchi, Rahil Nahid samiei, Mahboubeh Nahid samiei, Hassan Saadati, Pouya Moradi, Zahra Keyvanlou, Shoaib Advay, Marzie Nili, Samaneh Abdi, Tasnim Jamalvandi, null Arash letafati, Maral Behzadpour, Maryam Kamalpour, Niayesh Ebrahimdamavandi, Alireza Khatami, Seyed Jalal Kiani, and Saied Ghorbani
- Subjects
Polyomavirus Infections ,Infectious Diseases ,Brain Neoplasms ,Case-Control Studies ,Humans ,Polyomavirus ,Microbiology ,JC Virus - Abstract
The aim of this study was to investigate the prevalence and potential association between the infection with some members of the polyomaviridae family of viruses and development of the brain tumors.A systematic literature search was performed by finding relevant cross-sectional and case-control studies from a large online database. Heterogeneity, OR, and corresponding 95% CI were applied to all studies by meta-analysis and forest plots. The analysis was performed using Stata Software v.14.Twenty-three articles (33 datasets) were included in the meta-analysis, four (four datasets) of which were case/control studies and the rest were cross-sectional. The pooled prevalence of polyomaviruses among brain cancer patients was 13% (95% CI: 8-20%; IThe present study showed a significant association between polyomavirus infection and brain tumors. Moreover, these results suggest that polyomavirus infection may be a potential risk factor for the development of brain cancer.
- Published
- 2022