1. CuI and Copper Nanoparticles in the Catalytic Amination of 2-Halopyridines.
- Author
-
Kuliukhina, D. S., Averin, A. D., Panchenko, S. P., Abel, A. S., Savelyev, E. N., Orlinson, B. S., Novakov, I. A., Correia, C. R. D., and Beletskaya, I. P.
- Subjects
- *
AMINATION , *COPPER , *ADAMANTANE derivatives , *NANOPARTICLES , *CHEMICAL yield ,CATALYSTS recycling - Abstract
The N-heteroarylation of n-octylamine and adamantane-containing amines with 2-iodopyridine and 2-bromopyridine and its fluorinated derivatives under the catalysis of CuI and copper nanoparticles in DMSO in the presence of various ligands was studied. 2-Isobutyrylcyclohexanone was found to be the most efficient ligand in the reactions catalyzed by CuI. In the reactions catalyzed by copper nanoparticles, 2-isobutyrylcyclohexanone or l-proline turned to be most active. The yields of the reactions catalyzed by copper nanoparticles were better than or equal to those in the CuI-catalyzed processes. The possibility of nanocatalyst recycling was studied, and its reuse in 6 cycles without loss of activity was demonstrated. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF