1. Synthesis of polyglycerol-citric acid nanoparticles as biocompatible vectors for biomedical applications
- Author
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Mohsen Adeli, Ali Bodaghi, Abbas Dadkhahtehrani, and Zhaoxu Tu
- Subjects
Biocompatibility ,Silica gel ,Nanoparticle ,Nanotechnology ,macromolecular substances ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Biocompatible material ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,Catalysis ,chemistry.chemical_compound ,chemistry ,Materials Chemistry ,Glycerol ,Physical and Theoretical Chemistry ,0210 nano-technology ,Citric acid ,Spectroscopy - Abstract
Citric acid and glycerol play an important role in the food and drug industries. In this work, we present for the first time a facile and gram scale method for the preparation of polyglycerol-citric acid nanoparticles (PGCN) in the presence of silica gel blue as both catalyst and water removal agent. PGCN are highly biocompatible without significant toxicity up to 1 mg/ml. They are able to load small guest molecules and transfer them through the cell membrane, efficiently. Taking advantage of their straightforward synthesis and high biocompatibility as well as their ability to load and transfer small guest molecules, PGCN could be used for a variety of future biomedical applications.
- Published
- 2017
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