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Your search keyword '"Wenhuan He"' showing total 2 results
Start Over Author "Wenhuan He" Topic catalysis
2 results on '"Wenhuan He"'

1. Unexpected Brønsted Acid-Catalyzed Domino Reaction of 3-Hydroxyisoindolin-1-ones andN-tert-Butyl Hydrazones for the Synthesis of 3-(Hydrazono)isoindolin-1-ones

Author

Xiaoding Jiang, Liqin Qiu, Yongsu Li, Huixuan Chen, Gao-Feng Liu, Yuyang Zhang, Xuefeng He, Hao Liang, Yaqi Zhang, Wenhuan He, Rihui Cao, and Xiangmeng Chen

Subjects
Tert butyl, 010405 organic chemistry, Chemistry, Organic Chemistry, Homogeneous catalysis, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, 0104 chemical sciences, Catalysis, Cascade reaction, Organocatalysis, Physical and Theoretical Chemistry, Brønsted–Lowry acid–base theory
Published
2018
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2. Nickel(II)-catalyzed addition reaction of arylboronic acids to isatins

Author

Xuefeng He, Huixuan Chen, Liqin Qiu, Xiangmeng Chen, Xiaoding Jiang, Yaqi Zhang, Wenhuan He, Yongsu Li, Hao Liang, and Yuyang Zhang

Subjects
Addition reaction, 010405 organic chemistry, Ligand, Organic Chemistry, Enantioselective synthesis, chemistry.chemical_element, 010402 general chemistry, 01 natural sciences, Biochemistry, Medicinal chemistry, 0104 chemical sciences, Catalysis, Nickel, chemistry.chemical_compound, chemistry, Yield (chemistry), Drug Discovery, Phosphine
Abstract

A Ni-catalyzed addition of arylboronic acids to isatins was first developed. The reaction, driven by Ni(acac)2 and dppp as the phosphine ligand, gave 3-aryl-3-hydroxy-2-oxindoles in up to 97% yield. Scopes of benzyl-protected isatins and arylboronic acids were examined. Substituted phenylboronic acids along with fused-ring and heterocyclic boronic acids reacted with isatins smoothly. Preliminary asymmetric catalysis was investigated as well, showing moderate enantioselectivity. The mechanism was also described.

Published
2018
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