1. Preparation and Performance Study of a New Cinchonine-Based Catalyst.
- Author
-
Zhan, Murong, Wang, Zixuan, Yang, Yu, and Li, Chonglong
- Subjects
- *
ALDOLS , *CATALYSTS , *PERFORMANCE theory , *CHEMICAL synthesis , *AROMATIC aldehydes , *CYCLOHEXANONES , *RAW materials - Abstract
Using cinchonine as a raw material, a cinchonine-based isonitrile monomer was prepared after multistep transformation, and finally cinchonine-based catalyst was prepared by polymerization initiated by 4-methoxyphenylethynyl(chloro)bis(triethylphosphine)palladium(II). The new catalyst was used to catalyze asymmetric aldol reactions between cyclohexanone and aromatic aldehydes with different substituent groups. The reaction of cyclohexanone and 3-nitrobenzaldehyde in methanol afforded an enantiomeric excess (ee) value of up to 55% and a diastereomeric ratio (dr) of up to 30:70, indicating high performance of the catalyst. The synthesized compounds were characterized by HPLC, IR, and 1H NMR. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF