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Your search keyword '"Bizjajeva, Svetlana"' showing total 3 results
Start Over Author "Bizjajeva, Svetlana" Topic cataract
3 results on '"Bizjajeva, Svetlana"'

1. Congenital cataract screening in maternity wards is effective: evaluation of the Paediatric Cataract Register of Sweden.

Author

Magnusson G, Bizjajeva S, Haargaard B, Lundström M, Nyström A, and Tornqvist K

Subjects
Age Factors, Cataract epidemiology, Clinical Protocols, Female, Humans, Infant, Infant, Newborn, Male, Neonatal Screening, Prospective Studies, Retrospective Studies, Sweden epidemiology, Cataract congenital, Cataract diagnosis, Maternal-Child Health Centers, Obstetrics and Gynecology Department, Hospital, Registries
Abstract

Aim: To study which eye-screening protocol prevails in Swedish maternity/neonatal wards, evaluate efficacy in a prospective study and compare results with earlier Swedish retrospective results., Methods: Surveys were sent in 2006 to maternity/neonatal and women's health departments regarding screening policy. Response frequency was 96% (122/127). Data were derived from the Paediatric Cataract Register (PECARE), Sweden. All Swedish children diagnosed with congenital cataract and operated on before 1 year of age between January 2007 and December 2009 were included. Statistical comparison with earlier retrospective results was performed., Results: Eye screening is a routine protocol at a rate of 90% of Swedish maternity wards. Sixty-one children were included in the study. An increase was shown in case referrals from maternity wards compared to 10 years ago (64% vs. 50%). Detection was performed within 6 weeks of age in 75% of the cases. A significant difference between the probabilities of early referral (0.38; p < 0.001, < 6 weeks of age) and early surgery (0.36; p < 0.001) (PECARE) was found in comparison with the historical data of no maternity-ward screening. Well-baby clinics were instrumental in early detection, as well., Conclusion: Eye screening in maternity wards is effective. Clear Swedish directives are to be preferred., (©2012 The Author(s)/Acta Paediatrica ©2012 Foundation Acta Paediatrica.)

Published
2013
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2. [Eye screening in the maternity ward is efficient. Time for more distinct Swedish guidelines, according to prospective registry study].

Author

Magnusson G, Bizjajeva S, Haargaard B, Lundström M, Nyström A, and Tornqvist K

Subjects
Cataract diagnosis, Cataract epidemiology, Cataract Extraction statistics & numerical data, Humans, Infant, Infant, Newborn, Obstetrics and Gynecology Department, Hospital standards, Obstetrics and Gynecology Department, Hospital statistics & numerical data, Practice Guidelines as Topic, Prospective Studies, Referral and Consultation, Registries, Sweden epidemiology, Time Factors, Cataract congenital, Neonatal Screening economics, Neonatal Screening standards
Published
2012

3. Paediatric Fabry disease : prognostic significance of ocular changes for disease severity

Author

Kalkum, Gisela, Pitz, Susanne, Karabul, Nesrin, Beck, Michael, Pintos-Morell, Guillem, Parini, Rossella, Rohrbach, Marianne, Bizjajeva, Svetlana, Ramaswami, Uma, Universitat Autònoma de Barcelona, University of Zurich, and Kalkum, Gisela

Subjects
Male, 0301 basic medicine, Pediatrics, medicine.medical_specialty, Adolescent, Eye Diseases, Ocular signs, Severe disease, 610 Medicine & health, Severity of Illness Index, Cataract, Fabry Outcome Survey, Cornea, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Disease severity, medicine, Humans, Cornea verticillata, Eye Abnormalities, Prospective Studies, Eye Finding, Child, Children, Agalsidase alfa, Paediatric patients, Fabry disease, business.industry, Age Factors, Retinal Vessels, General Medicine, Prognosis, medicine.disease, 2731 Ophthalmology, Surgery, Ophthalmology, 030104 developmental biology, 10036 Medical Clinic, Child, Preschool, 030221 ophthalmology & optometry, Female, medicine.symptom, business, Research Article
Abstract

Altres ajuts: Medical writing support was provided by Margit Rezabek, DVM, PhD, of Excel Scientific Solutions and was funded by Shire. Shire was given the opportunity to review the manuscript. Ocular signs of Fabry disease can be seen in the first decade of life. We examined the occurrence of ocular signs in 232 paediatric patients in the Fabry Outcome Survey (FOS) international registry and looked for relationships between the presence of eye findings and disease severity as measured by the FOS Mainz severity score index (FOS-MSSI). At least one ocular sign was found in 55/101 (54.5%) girls and 62/131 (47.3%) boys: cornea verticillata in 53/101 (52.5%) girls and 55/131 (42.0%) boys, vessel tortuosity in 17/98 (17.3%) girls and 32/131 (24.4%) boys, and posterior spoke-like lens opacities in 3/97 (3.1%) girls and 2/130 (1.5%) boys. Summary statistics showed higher median (range) age-adjusted FOS-MSSI total score indicating more severe disease in children with eye findings versus those without eye findings (0.5 [−11.0, 20.7] versus −2.3 [−11.1, 18.8]). At least one eye finding was observed in 59.1% of treated and 37.9% of untreated children. We conclude that the presence of ocular signs, particularly cornea verticillata, correlates with more severe disease as indicated by FOS-MSSI scores in paediatric patients with Fabry disease. Ocular signs appear in roughly half of school-aged children with Fabry disease and are well-recognised as a valuable tool for diagnosis of Fabry disease in children; they also may help identify patients who are at risk for developing early severe manifestations of Fabry disease and who should be further evaluated and closely followed up. The online version of this article (doi:10.1186/s12886-016-0374-2) contains supplementary material, which is available to authorized users.

Published
2016

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