1. Two new vinblastine-type N-oxide alkaloids from Catharanthus roseus.
- Author
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Zhang WK, Xu JK, Tian HY, Wang L, Zhang XQ, Xiao XZ, Li P, and Ye WC
- Subjects
- Cell Proliferation drug effects, Hep G2 Cells, Humans, MCF-7 Cells, Magnetic Resonance Spectroscopy, Mass Spectrometry, Molecular Structure, Tetrazolium Salts, Thiazoles, Vinblastine chemistry, Vinblastine pharmacology, Catharanthus chemistry, Plant Leaves chemistry, Vinblastine analogs & derivatives, Vinblastine isolation & purification
- Abstract
Two new vinblastine-type N-oxide alkaloids, 17-desacetoxyvinblastine N'b-oxide (1) and 20'-deoxyvinblastine N'b-oxide (2), were isolated from the leaves of Catharanthus roseus. The structures of 1 and 2 were established by the analysis of their nuclear magnetic resonance and HR-ESI-MS spectroscopic data. All alkaloids were evaluated for their cytotoxic activities against the human hepatocellular carcinoma (HepG2) cell line, human colorectal carcinoma (Lovo) cell line and human breast carcinoma (MCF-7) cell line by the MTT method in vitro, respectively. The results showed that cytotoxic activities of alkaloids 1 and 2 exhibited moderate inhibitory activity on the proliferation of three cancer cells.
- Published
- 2013
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