1. Reducing Carbapenem Exposure: Extended-Spectrum β-Lactamase Catheter-Associated Urinary Tract Infection Management.
- Author
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Holt, Shannon, Grant, Mollie, and Thompson-Brazill, Kelly A.
- Subjects
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AMOXICILLIN , *ANTIBIOTICS , *BETA lactam antibiotics , *ENTEROBACTERIACEAE diseases , *CEFTAZIDIME , *CLAVULANIC acid , *CATHETERIZATION , *DRUG resistance in microorganisms , *ENTEROBACTERIACEAE , *HOST-bacteria relationships , *NURSING practice , *URINARY catheterization , *CONTINUING education units , *BACTERIURIA , *CARBAPENEMS , *MEDICAL device removal , *URINARY catheters , *CATHETER-associated urinary tract infections , *PREVENTION , *THERAPEUTICS , *SAFETY - Abstract
Catheter-associated urinary tract infections are one of the most common sources of infection, accounting for up to 40% of health care--associated infections each year in the United States. Extended-spectrum β-lactamase--producing Enterobacteriaceae are frequent causes of urinary tract infections in health care settings. Prevalent use of carbapenems has led to the emergence of carbapenem-resistant Enterobacteriaceae infections, leaving clinicians with few treatment options. Reducing carbapenem use and investigating alternative options for low-severity extended-spectrum β-lactamase infections is imperative to prevent more cases of carbapenem-resistant Enterobacteriaceae. Although carbapenems are the antibiotics of choice for treating extended-spectrum β-lactamase--producing Enterobacteriaceae catheter-associated urinary tract infections, carbapenem-sparing regimens may be appropriate for treating hemodynamically stable patients with low inoculum levels. Moreover, frontline health care providers can initiate efforts to reduce the development of multidrug-resistant organisms by decresing inappropriate antibiotic use during the treatment of catheter-associated asymptomatic bacteruria, avoiding unnecessary catheterizations, and avoiding culturing urine in asymptomatic patients. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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