1. Linfocitos B Cd23 Positivos y Cd23 Soluble: Relación con Concentraciones de IgE en Sangre de Cordon Umbilical de Recien Nacidos de Madres con o sin Antecedentes Alérgicos.
- Author
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Ascanio, Javier, Baldissera, José V., Castro, Johana, Malavé, María Eugenia, Flores, María Elisa, Chacón de Petrola, María de los R., Pacheco, Mariela, Colmenares, María, and Rivas, Harold Guevara
- Subjects
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CD antigens , *ATOPY , *NEWBORN infants , *B cells , *IMMUNOGLOBULIN E , *ALLERGIES - Abstract
This is a descriptive, cross*sectional, nonexperimental study of 76 newborn children (NB) (Maternity and Children Hospital Jose Maria Vargas, Valencia, Venezuela): 40 of them were delivered by mothers with allergy history and 36 without these antecedents. We quantified serum CD23s, IgE and the number of CD23m (+) B lymphocytes in the umbilical chord blood and these results were correlated with pregnancy exposure to house dust. CD23s - serum IgE was assayed by ELISA (Smartest Diagnostics). CD23m (blood) by flow cytometer Becton-Dickinson FACScan. Maternal age of total group (mean ± SD): 21.65 ± 4.88 years old. Male NB babies were 40.8%. Exposure to dust during pregnancy accounted for 81.6% and 40 NB had associated a maternal history of allergy (+). In total group: CD23s was 648 ± 248.6 pg / ml, 5.5 ± 9.7 IU IgE / mL, B lymphocytes CD23m (+): 316 ± 189.7 cells / uL. CD23s: NB with maternal history of allergy (+): 727.6 ± 291.7 pg / mL NB from mothers with no history: 561 43 ± 1504 pg / mL (p = 0.0012). CD23m in NB from mothers with history: 294 ± 1472 cells / uL. NB in mothers without allergy antecedents: 340.5 ± 227.6 cells / uL (p = 0.14), No statistical correlation was found between: CD23m and CD23s with IgE (total group). Maternal history of atopy and possible intrauterine sensitization process appears to be associated with elevated levels of CD23s in newborn babies. [ABSTRACT FROM AUTHOR]
- Published
- 2009