Search

Your search keyword '"Caré Alessandra"' showing total 1 results
Start Over Author "Caré Alessandra" Topic cd95
1 results on '"Caré Alessandra"'

1. Polyclonal expansion of CD3+/CD4+/CD56+ large granular lymphocytes and autoimmunity associated with dysregulation of Fas/FasL apoptotic pathway.

Author

Camagna, Antonio, Cedrone, Letizia, Caré, Alessandra, Samoggia, Paola, De Marco, Maria Civita, Del Duca, Pietro, De Martinis, Carlo, and Testa, Ugo

Subjects
CD antigens, LYMPHOCYTES, AUTOIMMUNITY, LIGANDS (Biochemistry)
Abstract

Evidence is accumulating regarding CD95/CD95 ligand (Fas/FasL) pathway dysregulation in clonal diseases of the lymphohaemopoietic lineages. According to these observations, it has been proposed that this defect may represent one of the mechanisms of tumour progression. In large granular lymphocyte (LGL) leukaemia, dysregulated apoptosis may represent a key event in the development of malignancy and autoimmunity. This case report describes dysregulation of the Fas/FasL pathway in a chronic polyclonal expansion of CD3+ LGLs associated with numerous serological immune abnormalities. [ABSTRACT FROM AUTHOR]

Published
2001
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results