1. Association study between ceftriaxone and a synthetic amide against strains of Pseudomonas aeruginosa.
- Author
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Rosa LLS, Andrade-Júnior FP, Cordeiro LV, Souza HDS, Athayde-Filho PF, Gadelha DDA, Melo DM, Silva DF, Alves DN, Sobreira ALC, Ferreira SRD, Teixeira APC, Farias BKS, Firmino RG, Maia AKHL, and Lima EO
- Subjects
- Pseudomonas aeruginosa, Amides, Anti-Bacterial Agents pharmacology, Microbial Sensitivity Tests, Ceftriaxone pharmacology, Anti-Infective Agents
- Abstract
Pseudomonas aeruginosa is a non-lactose fermenting Gram-negative bacteria responsible for causing numerous nosocomial infections. The present research aimed to analyze the anti-Pseudomonas aeruginosa potential of 2-Chloro-N-(4-fluoro-3-nitrophenyl)acetamide (A8). The antibacterial potential of A8 was evaluated from the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and Association using the checkerboard method. MIC and MBC values were 512 µg/mL for all P. aeruginosa strains evaluated, demonstrating predominantly bactericidal activity. Furthermore, when A8 was associated with the drug ceftriaxone, pharmacological additivity and indifference were evidenced. In this sense, the synthetic amide was interesting, since it demonstrates the potential to become a possible candidate for an antimicrobial drug.
- Published
- 2023
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