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Celiac disease (CD) has become a relatively prevalent disease which associates systemic manifestations mainly conditioned by the dysimmune response triggered by gluten diet. Its oral manifestations have been proven to lead to health disparities and impaired quality of life. Such findings include mainly dental enamel defects (DEDs) and recurrent aphthous stomatitis (RAS). Nevertheless, there are also some potentially severe oral conditions associated with CD, considered to be rare, among which various oral cancers, atrophic glossitis or glossodynia. Thus, the aim of our study was to perform a systematic-review of case presentations reporting rare oral findings associated with CD. The searching protocol was applied to EMBASE, OVID and PubMed. Both pediatric and adult patients were included. The identified conditions include: Plummer-Vinson Syndrome, atrophic glossitis, glossodynia and some oral cancers. Therefore, dental practitioners should be ready to suspect CD also in such rare cases, as prompt management of such conditions could prevent severe and even life threatening complications. [ABSTRACT FROM AUTHOR]

Celiac disease (CD) is responsible for digestive and systemic manifestations leading to moderate-to-severe health disparities and impaired quality of life for the affected patients. Several oral manifestations have been described, including mainly dental enamel defects (DEDs) and recurrent aphthous stomatitis (RAS). Nevertheless, publications on the topic reveal visible reporting discrepancies. Therefore, the aim of our study was to perform a systematic-review of case-controlled observational studies on CD oral manifestations. The searching protocol was applied to EMBASE, OVID and PubMed. Both pediatric and adult cohorts were included. The main oral manifestation in children was represented by DEDs, while RAS was rather reported in adults. Despite the relatively constant prevalence reported for such oral manifestations, publications are characterized by high publication and outcome bias. Moreover, oral manifestations are influenced by concurring the oral conditions possibly generated by diet and healthcare disparities. Thus, CD should be searched in patients with DEDs and aphthous ulcers or RAS, yet the concurring conditions should be ruled out, and a thorough CD diagnosis algorithm should be implemented. [ABSTRACT FROM AUTHOR]

Celiac disease (CD) is an autoimmune disorder occurring in genetically susceptible individuals, being characterized by inflammatory injury of the small intestine mucosa after ingestion of wheat gluten or related barley or rye products. The condition can develop at any age, although symptoms are most likely to appear during early childhood, between 9 and 18 months. Clinical presentation includes a family history and a range of symptoms such as recurrent abdominal pains, diarrhea, vomiting, bloating and flatulence, iron-deficiency anemia, weight loss, asthenia, and failure to thrive. The standard diagnostic criteria of CD require a clinical context, together with new serologic tests for antibodies against tissue transglutaminase and deamidated gliadin peptide, and especially characteristic histologic findings in small bowel biopsies (the gold standard for diagnosis). Gluten-free diet is the cornerstone therapy of CD. Although safe and effective, this method is not ideal: it is of limited nutritional value, expensive, and compliance or life quality problems are described in many countries. Consequently, alternative therapeutic strategies were developed to decrease the immunogenicity and to prevent the absorption of glutencontaining grains, together with strategies to limit T-cell migration or re-establish mucosal homeostasis. Celiac disease can appear in various associations, with atypical clinical presentation, requiring careful and early diagnosis for introducing the gluten-free diet as soon as possible, and for reducing the rate of subsequent complications. [ABSTRACT FROM AUTHOR]