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Your search keyword '"Zhijiang Song"' showing total 4 results
Start Over Author "Zhijiang Song" Topic cell adhesion
4 results on '"Zhijiang Song"'

1. A Poly(acrylic acid)-block- Poly(<scp>L</scp> -glutamic acid) Diblock Copolymer with Improved Cell Adhesion for Surface Modification

Author

Lei Cui, Xuesi Chen, Kunxi Zhang, Jingbo Yin, Tian Cao, Bin Cao, Shifeng Yan, and Zhijiang Song

Subjects
Polymers and Plastics, Biocompatibility, Chemistry, Chemical modification, Bioengineering, Adhesion, biochemical phenomena, metabolism, and nutrition, Biomaterials, chemistry.chemical_compound, Tissue engineering, Chemical engineering, Self-healing hydrogels, Polymer chemistry, Materials Chemistry, Surface modification, Cell adhesion, Biotechnology, Acrylic acid
Abstract

A novel PAA-b-PLGA diblock copolymer is synthesized and characterized that has excellent cell adhesion and biocompatibility. Fluorescent DiO labeling is used to monitor the attachment and growth of hASCs on the film surface, and cell proliferation over time is studied. Results show that PLLA modified by a CS/PAA-b-PLGA multilayer film can promote the attachment of human hASCs and provide an advantageous environment for their proliferation. The multilayer film presents excellent biocompatibility and cell adhesive properties, which will provide a new choice for improving the cell attachment in surface modification for tissue engineering. Hydroxyl, carboxyl and amine groups in the CS/PAA-b-PLGA multilayer film may be combined with drugs and growth factors for therapy and differentiation.

Published
2011
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2. Layer-by-layer assembled multilayer films of methoxypoly(ethylene glycol)-block-poly(α,l-glutamic acid) and chitosan with reduced cell adhesion

Author

Kunxi Zhang, Zhijiang Song, Lei Cui, Xuesi Chen, Jingbo Yin, Bin Cao, and Shifeng Yan

Subjects
Materials science, Polymers and Plastics, Polymers, Surface Properties, Glutamic Acid, Bioengineering, Polyethylene Glycols, Biomaterials, Chitosan, Contact angle, chemistry.chemical_compound, Adsorption, Coated Materials, Biocompatible, Polymer chemistry, Materials Testing, Materials Chemistry, Copolymer, Cell Adhesion, Cells, Cultured, Stem Cells, Layer by layer, Substrate (chemistry), Quartz crystal microbalance, Molecular Weight, chemistry, Ethylene glycol, Biotechnology
Abstract

A methoxypoly(ethylene glycol)-block-poly(alpha,L-glutamic acid) (mPEGGA) diblock copolymer is synthesized. Using QCM measurements, it is shown that (CS/mPEGGA)(n) film construction takes place over two build-up stages (exponential-to-linear). UV-vis spectra reveal the regular increase of the multilayer film growth at different molecular weights of mPEGGA. Contact angle and surface morphology investigation prove that the hydrophilicity of CS/mPEGGA multilayer film-modified substrate becomes better and the surface becomes rough. Significantly reduced cell adhesion is observed on the CS/mPEGGA multilayer film coated surface.

Published
2011

3. A poly(acrylic acid)-block-poly(L-glutamic acid) diblock copolymer with improved cell adhesion for surface modification

Author

Bin, Cao, Shifeng, Yan, Kunxi, Zhang, Zhijiang, Song, Tian, Cao, Xuesi, Chen, Lei, Cui, and Jingbo, Yin

Subjects
Drug Carriers, Tissue Scaffolds, Surface Properties, Stem Cells, Acrylic Resins, Cell Adhesion, Glutamic Acid, Humans, Biocompatible Materials, Hydrophobic and Hydrophilic Interactions, Cells, Cultured, Cell Proliferation
Abstract

A novel PAA-b-PLGA diblock copolymer is synthesized and characterized that has excellent cell adhesion and biocompatibility. Fluorescent DiO labeling is used to monitor the attachment and growth of hASCs on the film surface, and cell proliferation over time is studied. Results show that PLLA modified by a CS/PAA-b-PLGA multilayer film can promote the attachment of human hASCs and provide an advantageous environment for their proliferation. The multilayer film presents excellent biocompatibility and cell adhesive properties, which will provide a new choice for improving the cell attachment in surface modification for tissue engineering. Hydroxyl, carboxyl and amine groups in the CS/PAA-b-PLGA multilayer film may be combined with drugs and growth factors for therapy and differentiation.

Published
2011

4. Layer-by-layer buildup of poly(L-glutamic acid)/chitosan film for biologically active coating

Author

Zhijiang Song, Qiong Li, Jingbo Yin, Yan Yang, Shifeng Yan, Yanzhen Zheng, Kun Luo, and Xuesi Chen

Subjects
Materials science, Polymers and Plastics, Biocompatibility, Surface Properties, Bioengineering, Biocompatible Materials, Cell Line, Biomaterials, Chitosan, Myoblasts, chemistry.chemical_compound, Mice, Coated Materials, Biocompatible, Polymer chemistry, Materials Testing, Materials Chemistry, Cell Adhesion, Animals, Deposition (law), Cell Proliferation, Spectrum Analysis, Layer by layer, Polyglutamic acid, Quartz crystal microbalance, Hydrogen-Ion Concentration, Polyelectrolyte, chemistry, Chemical engineering, Polyglutamic Acid, Self-assembly, Biotechnology
Abstract

A new biocompatible film based on chitosan and poly(L-glutamic acid) (CS/PGA), created by alternate deposition of CS and PGA, was investigated. FT-IR spectroscopy, UV-vis spectroscopy and QCM were used to analyze the build-up process. The growth of CS and PGA deposition are both exponential to the deposition steps at first. After about 9 (CS/PGA) depositions, the exponential to linear transition takes place. QCM measurements combined with UV-vis spectra revealed the increase in the multilayer film growth at different pH (4.4, 5.0 and 5.5). The build-up of the multilayer stops after a few depositions at pH = 6.5. A muscle myoblast cell (C2C12) assay showed that (CS/PGA)(n) multilayer films obviously promote C2C12 attachment and growth.

Published
2008

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