1. Forever young: the key to rejuvenation during gametogenesis
- Author
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Bailey A Koch-Bojalad, Hong-Guo Yu, and Lauren Carson
- Subjects
Senescence ,Cell division ,Nuclear Envelope ,Extrachromosomal Inheritance ,Cellular homeostasis ,Saccharomyces cerevisiae ,Biology ,DNA, Ribosomal ,Gametogenesis ,Article ,03 medical and health sciences ,Genetics ,Asymmetric cell division ,medicine ,Homeostasis ,Rejuvenation ,Nuclear pore ,Cellular Senescence ,Cellular compartment ,030304 developmental biology ,0303 health sciences ,Endosomal Sorting Complexes Required for Transport ,030302 biochemistry & molecular biology ,General Medicine ,Cell biology ,Meiosis ,medicine.anatomical_structure ,Gamete ,Cell aging - Abstract
Cell aging is the result of deteriorating competence in maintaining cellular homeostasis and quality control. Certain cell types are able to rejuvenate through asymmetric cell division by excluding aging factors, including damaged cellular compartments and extra chromosomal rDNA circles, from entering the daughter cell. Recent findings from the budding yeast S. cerevisiae have shown that gametogenesis represents another type of cellular rejuvenation. Gametes, whether produced by an old or a young mother cell, are granted a renewed replicative lifespan through the formation of a fifth nuclear compartment that sequesters the harmful senescence factors accumulated by the mother. Here, we describe the importance and mechanism of cellular remodeling at the nuclear envelope mediated by ESCRT-III and the LEM-domain proteins, with a focus on nuclear pore biogenesis and chromatin interaction during gamete rejuvenation.
- Published
- 2020